Active: Age at menopause Clear all

GWAS 2025-12-05

No causal links between estradiol and female's brain and mental health using Mendelian randomization.

Oppenheimer H, van der Meer D et al.

Nat Commun

The role of estradiol in depression and Alzheimer's disease - brain disorders that disproportionatel...

Brain age gap

13423

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-02

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertili...

Number of children ever born

Replicated

819971

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-01

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.

D'Urso S, Arumugam P et al.

BMC Med

Observational epidemiological studies suggest a link between several factors related to ovulation an...

Age at last live birth

203153

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-29

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at natural menopause (ANM) is an important index for women's health. Either early or late ANM is...

Age at menopause

181219

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-10

Genetic associations with age of menopause in familial longevity.

Bae H, Lunetta KL et al.

Menopause

Objective: We hypothesize that mechanisms associated with extended reproductive age may overlap with...

Age at menopause

Replicated

10693

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-14

Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan.

Ruth KS, Soares ALG et al.

Hum Mol Genet

Anti-Müllerian hormone (AMH) is required for sexual differentiation in the fetus, and in adult femal...

Anti-Mullerian hormone levels in pre-menopausal women of late reproductive age

3344

Participants

N/A

Studies

Details PubMed

GWAS 2018-07-25

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.

Fernández-Rhodes L, Malinowski JR et al.

PLoS One

Current knowledge of the genetic architecture of key reproductive events across the female life cour...

Age at menopause

17730

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-17

Elucidating the genetic architecture of reproductive ageing in the Japanese population.

Horikoshi M, Day FR et al.

Nat Commun

Population studies elucidating the genetic architecture of reproductive ageing have been largely lim...

Menopause (age at onset)

Replicated

76406

Participants

N/A

Studies

Details PubMed

GWAS 2016-05-05

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

Mbarek H, Steinberg S et al.

Am J Hum Genet

Spontaneous dizygotic (DZ) twinning occurs in 1%-4% of women, with familial clustering and unknown p...

Spontaneous dizygotic twinning

Replicated

315878

Participants

N/A

Studies

Details PubMed

GWAS 2013-09-16

Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.

Pyun JA, Kim S et al.

Menopause

Objective: The aim of this study was to identify polymorphisms and gene-gene interactions that are s...

Menopause (age at onset)

1827

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-09

A genome-wide association study of early menopause and the combined impact of identified variants.

Perry JR, Corre T et al.

Hum Mol Genet

Early menopause (EM) affects up to 10% of the female population, reducing reproductive lifespan cons...

Menopause (age at onset)

Replicated

25431

Participants

N/A

Studies

Details PubMed

GWAS 2011-11-30

Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.

Chen CT, Fernández-Rhodes L et al.

Hum Mol Genet

Several genome-wide studies have identified loci associated with reproductive traits, such as ages o...

Menarche and menopause (age at onset)

3468

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

No causal links between estradiol and female's brain and mental health using Mendelian randomization.

Oppenheimer H, van der Meer D et al.

Nat Commun

Brain age gap

2025-12-05

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Number of children ever born

2023-03-02

Mendelian randomization analysis of factors related to ovulation and reproductive function and endometrial cancer risk.

D'Urso S, Arumugam P et al.

BMC Med

Age at last live birth

2022-11-01

Joint genome-wide association analyses identified 49 novel loci for age at natural menopause.

Zhang L, Wei XT et al.

J Clin Endocrinol Metab

Age at menopause

2021-05-29

Genetic associations with age of menopause in familial longevity.

Bae H, Lunetta KL et al.

Menopause

Age at menopause

2019-06-10

Genome-wide association study of anti-Müllerian hormone levels in pre-menopausal women of late reproductive age and relationship with genetic determinants of reproductive lifespan.

Ruth KS, Soares ALG et al.

Hum Mol Genet

Anti-Mullerian hormone levels in pre-menopausal women of late reproductive age

2019-01-14

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis.

Fernández-Rhodes L, Malinowski JR et al.

PLoS One

Age at menopause

2018-07-25

Elucidating the genetic architecture of reproductive ageing in the Japanese population.

Horikoshi M, Day FR et al.

Nat Commun

Menopause (age at onset)

2018-05-17

Identification of Common Genetic Variants Influencing Spontaneous Dizygotic Twinning and Female Fertility.

Mbarek H, Steinberg S et al.

Am J Hum Genet

Spontaneous dizygotic twinning

2016-05-05

Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.

Pyun JA, Kim S et al.

Menopause

Menopause (age at onset)

2013-09-16

A genome-wide association study of early menopause and the combined impact of identified variants.

Perry JR, Corre T et al.

Hum Mol Genet

Menopause (age at onset)

2013-01-09

Replication of loci influencing ages at menarche and menopause in Hispanic women: the Women's Health Initiative SHARe Study.

Chen CT, Fernández-Rhodes L et al.

Hum Mol Genet

Menarche and menopause (age at onset)

2011-11-30