Active: Asparaginase hypersensitivity in acute lymphoblastic leukemia Clear all

GWAS 2021-03-26

Class II HLA Variants Associate with Risk of Pegaspargase Hypersensitivity.

Liu Y, Yang W et al.

Clin Pharmacol Ther

We conducted the first human leukocyte antigen (HLA) allele and genome-wide association study to ide...

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2168

Participants

N/A

Studies

Details PubMed

GWAS 2015-05-18

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.

Fernandez CA, Smith C et al.

Blood

Asparaginase is used to treat acute lymphoblastic leukemia (ALL); however, hypersensitivity reaction...

Asparaginase hypersensitivity in acute lymphoblastic leukemia

Replicated

3308

Participants

N/A

Studies

Details PubMed

GWAS 2010-06-30

Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.

Chen SH, Pei D et al.

Clin Pharmacol Ther

The genetic variations that result in allergy to asparaginase are as yet undetermined. We interrogat...

Asparaginase hypersensitivity in acute lymphoblastic leukemia

Replicated

485

Participants

N/A

Studies

Details PubMed

Title

Author

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Class II HLA Variants Associate with Risk of Pegaspargase Hypersensitivity.

Liu Y, Yang W et al.

Clin Pharmacol Ther

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2021-03-26

Genome-wide analysis links NFATC2 with asparaginase hypersensitivity.

Fernandez CA, Smith C et al.

Blood

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2015-05-18

Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.

Chen SH, Pei D et al.

Clin Pharmacol Ther

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2010-06-30