Active: Axial length Clear all

GWAS 2023-07-31

Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations.

Han X, Pan S et al.

Br J Ophthalmol

Purpose: To investigate genetic loci associated with ocular axial length (AL) in the Chinese populat...

Ocular axial length

2644

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-05

A Genome-Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes.

Lu Q, Du Y et al.

Phenomics

High myopia has long been highly prevalent worldwide with a largely yet unexplained genetic contribu...

Axial length in high myopia

350

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-22

Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.

Fuse N, Sakurai M et al.

Ophthalmol Sci

Purpose: To elucidate the differences in ocular biometric parameters by generation and gender and to...

Axial length

33483

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-19

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Fan Q, Pozarickij A et al.

Commun Biol

Corneal curvature, a highly heritable trait, is a key clinical endophenotype for myopia - a major ca...

Corneal curvature

Replicated

132260

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-10

Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.

Shah RL, Guggenheim JA

Hum Genet

Previous studies have suggested that naturally occurring genetic variation contributes to the risk o...

Corneal astigmatism

86335

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-11

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.

Vergara C, Bomotti SM et al.

Hum Mutat

Refractive errors, myopia, and hyperopia are common visual disorders greatly affecting older individ...

Axial length

874

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-21

A univariate perspective of multivariate genome-wide association analysis.

Guo X, Zhu J et al.

Genet Epidemiol

Multiple correlated phenotypes are frequently collected in genome-wide association studies (GWASs), ...

Axial length

1055

Participants

N/A

Studies

Details PubMed

GWAS 2015-03-31

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

Miyake M, Yamashiro K et al.

Nat Commun

Myopia can cause severe visual impairment. Here, we report a two-stage genome-wide association study...

Axial length

Replicated

6708

Participants

N/A

Studies

Details PubMed

GWAS 2014-09-18

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.

Simpson CL, Wojciechowski R et al.

PLoS One

Refractive error (RE) is a complex, multifactorial disorder characterized by a mismatch between the ...

Hyperopia

Replicated

20933

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-24

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

Chen P, Miyake M et al.

Hum Mol Genet

Corneal curvature (CC) measures the steepness of the cornea and is an important parameter for clinic...

Corneal curvature

Replicated

12660

Participants

N/A

Studies

Details PubMed

GWAS 2013-08-08

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

Cheng CY, Schache M et al.

Am J Hum Genet

Refractive errors are common eye disorders of public health importance worldwide. Ocular axial lengt...

Axial length

Replicated

20747

Participants

N/A

Studies

Details PubMed

GWAS 2013-01-03

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.

Guggenheim JA, McMahon G et al.

Mol Vis

Purpose: Corneal curvature is a key determinant of the refractive power of the eye. Variants in two ...

Corneal curvature

Replicated

9383

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations.

Han X, Pan S et al.

Br J Ophthalmol

Ocular axial length

2023-07-31

A Genome-Wide Association Study for Susceptibility to Axial Length in Highly Myopic Eyes.

Lu Q, Du Y et al.

Phenomics

Axial length in high myopia

2022-12-05

Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study.

Fuse N, Sakurai M et al.

Ophthalmol Sci

Axial length

2022-01-22

Genome-wide association meta-analysis of corneal curvature identifies novel loci and shared genetic influences across axial length and refractive error.

Fan Q, Pozarickij A et al.

Commun Biol

Corneal curvature

2020-03-19

Genome-wide association studies for corneal and refractive astigmatism in UK Biobank demonstrate a shared role for myopia susceptibility loci.

Shah RL, Guggenheim JA

Hum Genet

Corneal astigmatism

2018-10-10

Association analysis of exome variants and refraction, axial length, and corneal curvature in a European-American population.

Vergara C, Bomotti SM et al.

Hum Mutat

Axial length

2018-09-11

A univariate perspective of multivariate genome-wide association analysis.

Guo X, Zhu J et al.

Genet Epidemiol

Axial length

2018-05-21

Identification of myopia-associated WNT7B polymorphisms provides insights into the mechanism underlying the development of myopia.

Miyake M, Yamashiro K et al.

Nat Commun

Axial length

2015-03-31

Genome-wide meta-analysis of myopia and hyperopia provides evidence for replication of 11 loci.

Simpson CL, Wojciechowski R et al.

PLoS One

Hyperopia

2014-09-18

CMPK1 and RBP3 are associated with corneal curvature in Asian populations.

Chen P, Miyake M et al.

Hum Mol Genet

Corneal curvature

2014-06-24

Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.

Cheng CY, Schache M et al.

Am J Hum Genet

Axial length

2013-08-08

A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor α gene as a quantitative trait locus for eye size in white Europeans.

Guggenheim JA, McMahon G et al.

Mol Vis

Corneal curvature

2013-01-03