Active: Cerebral small vessel disease Clear all

GWAS 2024-03-25

Does Thrombosis Play a Causal Role in Lacunar Stroke and Cerebral Small Vessel Disease?

Koohi F, Harshfield EL et al.

Stroke

The importance of thromboembolism in the pathogenesis of lacunar stroke (LS), resulting from cerebra...

White matter hyperintensities

37355

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-17

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Duperron MG, Knol MJ et al.

Nat Med

Perivascular space (PVS) burden is an emerging, poorly understood, magnetic resonance imaging marker...

Extensive white matter perivascular space burden

Replicated

38598

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-02

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.

Mishra A, Duplaà C et al.

Brain

Cerebral small vessel disease is a leading cause of stroke and a major contributor to cognitive decl...

Cerebral small vessel disease

19721

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-08

Cerebral small vessel disease genomics and its implications across the lifespan.

Sargurupremraj M, Suzuki H et al.

Nat Commun

White matter hyperintensities (WMH) are the most common brain-imaging feature of cerebral small vess...

White matter hyperintensity volume x hypertension interaction (2df)

46055

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-01

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.

Persyn E, Hanscombe KB et al.

Nat Commun

Cerebral small vessel disease is a major cause of stroke and dementia, but its genetic basis is inco...

White matter hyperintensities

45204

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-20

Genome-wide association study of cerebral small vessel disease reveals established and novel loci.

Chung J, Marini S et al.

Brain

Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations ...

Non-lobar intracerebral hemorrhage

2716

Participants

N/A

Studies

Details PubMed

GWAS 2018-08-01

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Jian X, Satizabal CL et al.

Stroke

Background and Purpose- White matter hyperintensities (WMH) on brain magnetic resonance imaging are ...

White matter hyperintensities

Replicated

11911

Participants

N/A

Studies

Details PubMed

GWAS 2018-05-11

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Rutten-Jacobs LCA, Tozer DJ et al.

Stroke

Background and purpose: Structural integrity of the white matter is a marker of cerebral small vesse...

White matter integrity (fractional anisotropy)

8239

Participants

N/A

Studies

Details PubMed

GWAS 2016-12-20

Genetic variation at 16q24.2 is associated with small vessel stroke.

Traylor M, Malik R et al.

Ann Neurol

Objective: Genome-wide association studies (GWAS) have been successful at identifying associations w...

Ischemic stroke

Replicated

48208

Participants

N/A

Studies

Details PubMed

GWAS 2014-02-27

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.

Opherk C, Gonik M et al.

Stroke

Background and purpose: White matter hyperintensities (WMH) on MRI are a quantitative marker for spo...

White matter hyperintensity volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

466

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Does Thrombosis Play a Causal Role in Lacunar Stroke and Cerebral Small Vessel Disease?

Koohi F, Harshfield EL et al.

Stroke

White matter hyperintensities

2024-03-25

Genomics of perivascular space burden unravels early mechanisms of cerebral small vessel disease.

Duperron MG, Knol MJ et al.

Nat Med

Extensive white matter perivascular space burden

2023-04-17

Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate.

Mishra A, Duplaà C et al.

Brain

Cerebral small vessel disease

2022-05-02

Cerebral small vessel disease genomics and its implications across the lifespan.

Sargurupremraj M, Suzuki H et al.

Nat Commun

White matter hyperintensity volume x hypertension interaction (2df)

2020-12-08

Genome-wide association study of MRI markers of cerebral small vessel disease in 42,310 participants.

Persyn E, Hanscombe KB et al.

Nat Commun

White matter hyperintensities

2020-05-01

Genome-wide association study of cerebral small vessel disease reveals established and novel loci.

Chung J, Marini S et al.

Brain

Non-lobar intracerebral hemorrhage

2019-08-20

Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging.

Jian X, Satizabal CL et al.

Stroke

White matter hyperintensities

2018-08-01

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia.

Rutten-Jacobs LCA, Tozer DJ et al.

Stroke

White matter integrity (fractional anisotropy)

2018-05-11

Genetic variation at 16q24.2 is associated with small vessel stroke.

Traylor M, Malik R et al.

Ann Neurol

Ischemic stroke

2016-12-20

Genome-wide genotyping demonstrates a polygenic risk score associated with white matter hyperintensity volume in CADASIL.

Opherk C, Gonik M et al.

Stroke

White matter hyperintensity volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy

2014-02-27