Active: Chronic kidney disease Clear all

GWAS 2025-10-10

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function.

Monteiro-Martins S, Li Y et al.

Kidney Int

Introduction: Chronic kidney disease (CKD) is defined as sustained abnormalities in kidney function ...

Kidney volume

38816

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-04

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

We addressed the underrepresentation of non-European populations in genome-wide association studies ...

Acute vascular insufficiency of intestine (PheCode 441.1)

228734

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-10

Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function.

D'Antonio M, Arthur TD et al.

Hum Mol Genet

The rising prevalence of chronic kidney disease (CKD), affecting an estimated 37 million adults in t...

Estimated glomerular filtration rate based on creatinine (2009 formula) in top 10% of individuals by creatinine levels

40170

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-02

Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.

Chen Y, Torta F et al.

Diabetologia

Aims/hypothesis: This study aims to explore the association between plasma metabolites and chronic k...

Cholesterol ester (CE.22.5) levels in type 2 diabetes

6350

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-20

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas.

Hughes O, Bentley AR et al.

Cell Genom

Chronic kidney disease is a leading cause of death and disability globally and impacts individuals o...

Estimated glomerular filtration rate

145732

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-04

Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases.

Homilius M, Zhu W et al.

Nat Genet

Although genome-wide association studies (GWAS) have successfully linked genetic risk loci to variou...

Immature platelet fraction perturbation response (side fluorescence standard deviation of IPF at baseline measured by platelet-F dye)

1681

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-03

Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.

Lee DJ, Moon JS et al.

Kidney Res Clin Pract

Chronic kidney disease is a significant health burden worldwide, with increasing incidence. Although...

Estimated glomerular filtration rate

58406

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-12

Genome-Wide Association Studies for Albuminuria of non-Diabetic Taiwanese Population.

Yang WS, Chuang GT et al.

Am J Nephrol

Introduction: Chronic kidney disease, which is defined by a reduced estimated glomerular filtration ...

Albuminuria

6768

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-05

Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.

Schlosser P, Scherer N et al.

Nat Genet

The kidneys operate at the interface of plasma and urine by clearing molecular waste products while ...

Plasma N-acetylglutamate levels in chronic kidney disease

4958

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-10

Identification of Genetic Markers Linked to The Activity of Indoleamine 2,3-Dioxygenase and Kidney Function.

Kim HR, Jin HS et al.

Metabolites

Indoleamine 2,3-dioxygenase (IDO) is a tryptophan-degrading enzyme belonging to the kynurenine pathw...

Indoleamine 2,3-dioxygenase activity

2579

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-11

Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis.

Jin H, Kim YA et al.

BMC Med

The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic fa...

Diabetic kidney disease

33879

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-05

Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

Han M, Moon S et al.

J Am Soc Nephrol

Significance statement: eGFR slope has been used as a surrogate outcome for progression of CKD. Howe...

eGFR slope in chronic kidney disease

Replicated

4236

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic screens of imaging-derived kidney volumes identify genes linked to kidney function.

Monteiro-Martins S, Li Y et al.

Kidney Int

Kidney volume

2025-10-10

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

Acute vascular insufficiency of intestine (PheCode 441.1)

2025-06-04

Genetic analysis of elevated levels of creatinine and cystatin C biomarkers reveals novel genetic loci associated with kidney function.

D'Antonio M, Arthur TD et al.

Hum Mol Genet

Estimated glomerular filtration rate based on creatinine (2009 formula) in top 10% of individuals by creatinine levels

2025-02-10

Metabolomics profiling in multi-ancestral individuals with type 2 diabetes in Singapore identified metabolites associated with renal function decline.

Chen Y, Torta F et al.

Diabetologia

Cholesterol ester (CE.22.5) levels in type 2 diabetes

2024-12-02

Genome-wide study investigating effector genes and polygenic prediction for kidney function in persons with ancestry from Africa and the Americas.

Hughes O, Bentley AR et al.

Cell Genom

Estimated glomerular filtration rate

2023-12-20

Perturbational phenotyping of human blood cells reveals genetically determined latent traits associated with subsets of common diseases.

Homilius M, Zhu W et al.

Nat Genet

Immature platelet fraction perturbation response (side fluorescence standard deviation of IPF at baseline measured by platelet-F dye)

2023-12-04

Genome-wide association study and fine-mapping on Korean biobank to discover renal trait-associated variants.

Lee DJ, Moon JS et al.

Kidney Res Clin Pract

Estimated glomerular filtration rate

2023-11-03

Genome-Wide Association Studies for Albuminuria of non-Diabetic Taiwanese Population.

Yang WS, Chuang GT et al.

Am J Nephrol

Albuminuria

2023-07-12

Genetic studies of paired metabolomes reveal enzymatic and transport processes at the interface of plasma and urine.

Schlosser P, Scherer N et al.

Nat Genet

Plasma N-acetylglutamate levels in chronic kidney disease

2023-06-05

Identification of Genetic Markers Linked to The Activity of Indoleamine 2,3-Dioxygenase and Kidney Function.

Kim HR, Jin HS et al.

Metabolites

Indoleamine 2,3-dioxygenase activity

2023-04-10

Identification of genetic variants associated with diabetic kidney disease in multiple Korean cohorts via a genome-wide association study mega-analysis.

Jin H, Kim YA et al.

BMC Med

Diabetic kidney disease

2023-01-11

Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

Han M, Moon S et al.

J Am Soc Nephrol

eGFR slope in chronic kidney disease

2023-01-05