Active: Chronic lymphocytic leukemia Clear all

GWAS 2022-10-22

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Berndt SI, Vijai J et al.

Leukemia

Lymphoma risk is elevated for relatives with common non-Hodgkin lymphoma (NHL) subtypes, suggesting ...

Non-Hodgkin lymphoma subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, or marginal zone lymphoma) (pleiotropy)

Replicated

26787

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-28

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

Lin WY, Fordham SE et al.

Nat Commun

Prognostication in patients with chronic lymphocytic leukemia (CLL) is challenging due to heterogene...

Chronic lymphocytic leukemia (time to first treatment)

Replicated

842

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-13

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

Din L, Sheikh M et al.

Genet Epidemiol

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmu...

Chronic lymphocytic leukemia or multiple sclerosis

36793

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-14

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relation to chronic lymphocytic leukemia.

Chen X, Gustafsson S et al.

Hum Mol Genet

Phosphorylcholine (PC) is an epitope on oxidized low-density lipoprotein (oxLDL), apoptotic cells an...

Immunoglobulin M against phosphorylcholine (IgM anti-PC) levels

Replicated

3648

Participants

N/A

Studies

Details PubMed

GWAS 2017-02-06

Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

Law PJ, Berndt SI et al.

Nat Commun

Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of...

Chronic lymphocytic leukemia

Replicated

23798

Participants

N/A

Studies

Details PubMed

GWAS 2017-01-23

Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci.

Law PJ, Sud A et al.

Sci Rep

B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages...

B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy)

14421

Participants

N/A

Studies

Details PubMed

GWAS 2016-03-09

Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.

Berndt SI, Camp NJ et al.

Nat Commun

Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To furt...

Chronic lymphocytic leukemia

Replicated

18255

Participants

N/A

Studies

Details PubMed

GWAS 2013-12-01

A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.

Speedy HE, Di Bernardo MC et al.

Nat Genet

Genome-wide association studies (GWAS) of chronic lymphocytic leukemia (CLL) have shown that common ...

Chronic lymphocytic leukemia

Replicated

11233

Participants

N/A

Studies

Details PubMed

GWAS 2013-06-16

Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.

Berndt SI, Skibola CF et al.

Nat Genet

Genome-wide association studies (GWAS) have previously identified 13 loci associated with risk of ch...

Chronic lymphocytic leukemia

Replicated

16427

Participants

N/A

Studies

Details PubMed

GWAS 2012-06-13

Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.

Slager SL, Skibola CF et al.

Blood

We performed a meta-analysis of 3 genome-wide association studies to identify additional common vari...

Chronic lymphocytic leukemia

Replicated

7760

Participants

N/A

Studies

Details PubMed

GWAS 2011-06-09

Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.

Wade R, Di Bernardo MC et al.

Haematologica

There is variability in the outcome of patients with chronic lymphocytic leukemia with apparently th...

Response to antineoplastic agents

Replicated

736

Participants

N/A

Studies

Details PubMed

GWAS 2010-12-03

Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

Slager SL, Rabe KG et al.

Blood

Prior genome-wide association (GWA) studies have identified 10 susceptibility loci for risk of chron...

Chronic lymphocytic leukemia

Replicated

1920

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Distinct germline genetic susceptibility profiles identified for common non-Hodgkin lymphoma subtypes.

Berndt SI, Vijai J et al.

Leukemia

Non-Hodgkin lymphoma subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, or marginal zone lymphoma) (pleiotropy)

2022-10-22

Genome-wide association study identifies risk loci for progressive chronic lymphocytic leukemia.

Lin WY, Fordham SE et al.

Nat Commun

Chronic lymphocytic leukemia (time to first treatment)

2021-01-28

Genetic overlap between autoimmune diseases and non-Hodgkin lymphoma subtypes.

Din L, Sheikh M et al.

Genet Epidemiol

Chronic lymphocytic leukemia or multiple sclerosis

2019-08-13

A genome-wide association study of IgM antibody against phosphorylcholine: shared genetics and phenotypic relation to chronic lymphocytic leukemia.