Active: Cleft lip with or without cleft palate Clear all

GWAS 2024-11-06

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

Rahimov F, Nieminen P et al.

Nat Commun

In Finland, the frequency of isolated cleft palate (CP) is higher than that of isolated cleft lip wi...

Nonsyndromic cleft palate

Replicated

708171

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-18

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Nonsyndromic orofacial clefts (NSOFCs) represent a large proportion (70%-80%) of all OFCs. They can ...

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

3178

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-01

Integrative Multi-omics Analysis Identifies Genetic Variants Contributing to Non-syndromic Cleft Lip with or without Cleft Palate.

Lou S, Yang J et al.

Chin J Dent Res

Objective: To provide novel insights into the aetiology of non-syndromic cleft lip with or without c...

Nonsyndromic cleft lip with or without cleft palate

Replicated

2793

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-10

Genome-wide Interaction Study Implicates VGLL2 and Alcohol Exposure and PRL and Smoking in Orofacial Cleft Risk.

Carlson JC, Shaffer JR et al.

Front Cell Dev Biol

Non-syndromic cleft lip with or without cleft palate (NSCL/P) is a common birth defect, affecting ap...

Orofacial cleft x maternal alcohol consumption interaction (2df)

538

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-08

Identification of Novel Genomic Variations in Susceptibility to Nonsyndromic Cleft Lip and Palate Patients.

Avasthi KK, Muthuswamy S et al.

Pediatr Rep

Nonsyndromic cleft lip with or without palate (NSCL/P) is a multifactorial and common birth malforma...

Nonsyndromic cleft lip with or without cleft palate

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-23

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.

Awotoye W, Comnick C et al.

J Dent Res

Risk loci identified through genome-wide association studies have explained about 25% of the phenoty...

Nonsyndromic orofacial cleft x sex interaction

3178

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-09

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.

Ray D, Venkataraghavan S et al.

PLoS Genet

Based on epidemiologic and embryologic patterns, nonsyndromic orofacial clefts- the most common cran...

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

10146

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-09

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions.

Mukhopadhyay N, Feingold E et al.

Front Cell Dev Biol

Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create...

Nonsyndromic cleft lip with or without cleft palate

9447

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-22

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.

Indencleef K, Hoskens H et al.

Front Genet

Unaffected relatives of individuals with non-syndromic cleft lip with or without cleft palate (NSCL/...

Facial morphology traits (59 NSCL/P endophenotypic segments)

8246

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-06

Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian-randomization study.

Dardani C, Howe LJ et al.

Int J Epidemiol

Previous studies have found that children born with a non-syndromic orofacial cleft have lower-than-...

Cleft lip with or without cleft palate

5951

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-24

A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.

Haaland ØA, Romanowska J et al.

F1000Res

Although both genetic and environmental factors have been reported to influence the risk of isolated...

Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect)

5424

Participants

N/A

Studies

Details PubMed

GWAS 2018-11-19

Genomic analyses in african populations identify novel risk loci for cleft palate.

Butali A, Mossey PA et al.

Hum Mol Genet

Orofacial clefts are common developmental disorders that pose significant clinical, economical and p...

Cleft lip with or without cleft palate

Replicated

4429

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

Rahimov F, Nieminen P et al.

Nat Commun

Nonsyndromic cleft palate

2024-11-06

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Alade A, Peter T et al.

Genet Epidemiol

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

2024-04-18

Integrative Multi-omics Analysis Identifies Genetic Variants Contributing to Non-syndromic Cleft Lip with or without Cleft Palate.

Lou S, Yang J et al.

Chin J Dent Res

Nonsyndromic cleft lip with or without cleft palate

2024-03-01

Genome-wide Interaction Study Implicates VGLL2 and Alcohol Exposure and PRL and Smoking in Orofacial Cleft Risk.

Carlson JC, Shaffer JR et al.

Front Cell Dev Biol

Orofacial cleft x maternal alcohol consumption interaction (2df)

2022-02-10

Identification of Novel Genomic Variations in Susceptibility to Nonsyndromic Cleft Lip and Palate Patients.

Avasthi KK, Muthuswamy S et al.

Pediatr Rep

Nonsyndromic cleft lip with or without cleft palate

2021-12-08

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.

Awotoye W, Comnick C et al.

J Dent Res

Nonsyndromic orofacial cleft x sex interaction

2021-10-23

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.

Ray D, Venkataraghavan S et al.

PLoS Genet

Cleft lip with or without cleft palate or cleft palate (pleiotropy)

2021-07-09

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions.

Mukhopadhyay N, Feingold E et al.

Front Cell Dev Biol

Nonsyndromic cleft lip with or without cleft palate

2021-04-09

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.

Indencleef K, Hoskens H et al.

Front Genet

Facial morphology traits (59 NSCL/P endophenotypic segments)

2021-02-22

Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian-randomization study.

Dardani C, Howe LJ et al.

Int J Epidemiol

Cleft lip with or without cleft palate

2020-05-06

A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.

Haaland ØA, Romanowska J et al.

F1000Res

Cleft lip with or without cleft palate x maternal periconceptional alcohol use interaction (parent of origin effect)

2019-06-24

Genomic analyses in african populations identify novel risk loci for cleft palate.

Butali A, Mossey PA et al.

Hum Mol Genet

Cleft lip with or without cleft palate

2018-11-19

Health & Traits Publications

High incidence and geographic distribution of cleft palate in Finland are associated with the IRF6 gene.

Shared genetic risk between major orofacial cleft phenotypes in an African population.

Integrative Multi-omics Analysis Identifies Genetic Variants Contributing to Non-syndromic Cleft Lip with or without Cleft Palate.

Genome-wide Interaction Study Implicates <i>VGLL2</i> and Alcohol Exposure and <i>PRL</i> and Smoking in Orofacial Cleft Risk.

Identification of Novel Genomic Variations in Susceptibility to Nonsyndromic Cleft Lip and Palate Patients.

Genome-wide Gene-by-Sex Interaction Studies Identify Novel Nonsyndromic Orofacial Clefts Risk Locus.

Pleiotropy method reveals genetic overlap between orofacial clefts at multiple novel loci from GWAS of multi-ethnic trios.

Genome-Wide Association Study of Non-syndromic Orofacial Clefts in a Multiethnic Sample of Families and Controls Identifies Novel Regions.

The Intersection of the Genetic Architectures of Orofacial Clefts and Normal Facial Variation.

Cleft lip/palate and educational attainment: cause, consequence or correlation? A Mendelian-randomization study.

A genome-wide scan of cleft lip triads identifies parent-of-origin interaction effects between ANK3 and maternal smoking, and between ARHGEF10 and alcohol consumption.

Genomic analyses in african populations identify novel risk loci for cleft palate.