Active: Cognitive decline Clear all

GWAS 2025-07-29

Whole Genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese.

Wang M, Sun L et al.

Genomics Proteomics Bioinformatics

Subjective cognitive decline (SCD) is widely regarded as a potential preclinical stage of Alzheimer'...

Subjective cognitive decline

Replicated

10763

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-15

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.

Schoeler T, Pingault JB et al.

Nat Commun

Large-scale genomic studies focusing on the genetic contribution to human aging have mostly relied o...

Fluid intelligence score decline (difference score)

131736

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-14

GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson's disease.

Li C, Hou Y et al.

J Gerontol A Biol Sci Med Sci

Cognitive decline is among the most common non-motor symptoms in Parkinson's disease (PD), while its...

Cognitive performance in Parkinson's disease

1529

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-16

Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort.

Sáez ME, García-Sánchez A et al.

Alzheimers Res Ther

Several studies have reported a relationship between retinal thickness and dementia. Therefore, opti...

Retinal nerve fibre layer (RNFL) thickness

3170

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-31

Disentangling Accelerated Cognitive Decline from the Normal Aging Process and Unraveling Its Genetic Components: A Neuroimaging-Based Deep Learning Approach.

Dai Y, Hsu YC et al.

J Alzheimers Dis

The progressive cognitive decline, an integral component of Alzheimer's disease (AD), unfolds in tan...

Accelerated cognitive decline

1064

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-21

A Genome-Wide Interaction Study of Erythrocyte ω3 Polyunsaturated Fatty Acid Species and Memory in The Framingham Heart Study Offspring Cohort.

Annevelink CE, Westra J et al.

J Nutr

Cognitive decline, and more specifically Alzheimer's disease, continues to increase in prevalence gl...

Alpha-linoleic acid levels and Trail making test A (interaction)

1620

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-01

Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.

Liu M, Khasiyev F et al.

J Am Heart Assoc

Brain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive d...

Global brain arterial diameters

4150

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-23

Genetic Variants Associated with Longitudinal Cognitive Performance in Older Breast Cancer Patients and Controls.

Nudelman K, Nho K et al.

Cancers (Basel)

There have been no published genome-wide studies of the genetics of cancer- and treatment-related co...

Longitudinal cognitive performance (attention, processing and executive function) x breast cancer interaction

665

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-23

Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.

Acharya V, Fan KH et al.

Alzheimers Dement

Introduction: Cognitive abilities have substantial heritability throughout life, as shown by twin- a...

Cognitive performance (attention) (longitudinal)

3042

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-11

Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.

Brown AL, Sok P et al.

Neuro Oncol

Survivors of pediatric central nervous system (CNS) tumors treated with craniospinal irradiation (CS...

Change in intelligence quotient in pediatric CNS tumors treated with craniospinal irradiation

Replicated

223

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-29

General dimensions of human brain morphometry inferred from genome-wide association data.

Fürtjes AE, Arathimos R et al.

Hum Brain Mapp

Understanding the neurodegenerative mechanisms underlying cognitive decline in the general populatio...

Brain stem volume (UKB data field 26526)

36778

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-09

Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia.

Real R, Martinez-Carrasco A et al.

Brain

Parkinson's disease is one of the most common age-related neurodegenerative disorders. Although pred...

Parkinson’s disease progression to dementia

3923

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Whole Genome Sequence Analysis Revealed Novel Subjective Cognitive Decline-associated Genes in 10,763 Chinese.

Wang M, Sun L et al.

Genomics Proteomics Bioinformatics

Subjective cognitive decline

2025-07-29

Combining cross-sectional and longitudinal genomic approaches to identify determinants of cognitive and physical decline.

Schoeler T, Pingault JB et al.

Nat Commun

Fluid intelligence score decline (difference score)

2025-05-15

GWAS identifies DPP6 as risk gene of cognitive decline in Parkinson's disease.

Li C, Hou Y et al.

J Gerontol A Biol Sci Med Sci

Cognitive performance in Parkinson's disease

2024-06-14

Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohort.

Sáez ME, García-Sánchez A et al.

Alzheimers Res Ther

Retinal nerve fibre layer (RNFL) thickness

2024-02-16

Disentangling Accelerated Cognitive Decline from the Normal Aging Process and Unraveling Its Genetic Components: A Neuroimaging-Based Deep Learning Approach.

Dai Y, Hsu YC et al.

J Alzheimers Dis

Accelerated cognitive decline

2024-01-31

A Genome-Wide Interaction Study of Erythrocyte ω3 Polyunsaturated Fatty Acid Species and Memory in The Framingham Heart Study Offspring Cohort.

Annevelink CE, Westra J et al.

J Nutr

Alpha-linoleic acid levels and Trail making test A (interaction)

2023-12-21

Chromosome 10q24.32 Variants Associate With Brain Arterial Diameters in Diverse Populations: A Genome-Wide Association Study.

Liu M, Khasiyev F et al.

J Am Heart Assoc

Global brain arterial diameters

2023-12-01

Genetic Variants Associated with Longitudinal Cognitive Performance in Older Breast Cancer Patients and Controls.

Nudelman K, Nho K et al.

Cancers (Basel)

Longitudinal cognitive performance (attention, processing and executive function) x breast cancer interaction

2023-05-23

Meta-analysis of age-related cognitive decline reveals a novel locus for the attention domain and implicates a COVID-19-related gene for global cognitive function.

Acharya V, Fan KH et al.

Alzheimers Dement

Cognitive performance (attention) (longitudinal)

2023-04-23

Genetic susceptibility to cognitive decline following craniospinal irradiation for pediatric central nervous system tumors.

Brown AL, Sok P et al.

Neuro Oncol

Change in intelligence quotient in pediatric CNS tumors treated with craniospinal irradiation

2023-04-11

General dimensions of human brain morphometry inferred from genome-wide association data.

Fürtjes AE, Arathimos R et al.

Hum Brain Mapp

Brain stem volume (UKB data field 26526)

2023-03-29

Association between the LRP1B and APOE loci in the development of Parkinson's disease dementia.

Real R, Martinez-Carrasco A et al.

Brain

Parkinson’s disease progression to dementia

2022-11-09