Active: Coronary heart disease Clear all

GWAS 2024-07-19

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Verma A, Huffman JE et al.

Science

One of the justifiable criticisms of human genetic studies is the underrepresentation of participant...

Takes medication for coronary artery/ coronary heart disease?

404034

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-09

Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.

Liao Y, Yu H et al.

Mol Psychiatry

Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic medication and may...

Antipsychotic-induced HDL-cholesterol change in schizophrenia (4-week)

Replicated

1936

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-01

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.

Tam CHT, Lim CKP et al.

Diabetes Care

Objective: In this study we aim to unravel genetic determinants of coronary heart disease (CHD) in t...

Coronary heart disease in type 2 diabetes

Replicated

17534

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-26

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morb...

Right ventricular end diastolic volume

35941

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-31

Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study.

Durda P, Raffield LM et al.

J Am Heart Assoc

Background Monocytes/macrophages participate in cardiovascular disease. CD163 (cluster of differenti...

Soluble CD163 levels

Replicated

3777

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-12

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.

Saad M, El-Menyar A et al.

Circ Genom Precis Med

Enthusiasm for using polygenic risk scores (PRSs) in clinical practice is tempered by concerns about...

Coronary heart disease

Replicated

1431297

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-14

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.

Dungan JR, Qin X et al.

Am Heart J Plus

Ischemic coronary heart disease (IHD) is the leading cause of death worldwide. Genetic variation is ...

Survival in coronary artery disease

510

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-15

Genetic and observational evidence: No independent role for cholesterol efflux over static HDL concentration measures in CHD risk assessment.

Kuusisto S, Karjalainen MK et al.

J Intern Med

Observational findings for high-density lipoprotein (HDL)-mediated cholesterol efflux capacity (HDL-...

High-density lipoprotein mediated cholesterol efflux capacity

20372

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-05

The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction.

Trompet S, Postmus I et al.

Front Pharmacol

The pharmacogenetic effect on cardiovascular disease reduction in response to statin treatment has o...

Myocardial infraction risk reduction in statin users

Replicated

12294

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-02

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans.

Soremekun O, Soremekun C et al.

Front Genet

White blood cell (WBC) traits and their subtypes such as basophil count (Bas), eosinophil count (Eos...

Monocyte count

16152

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-10

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.

Pazoki R, Vujkovic M et al.

Nat Commun

Serum concentration of hepatic enzymes are linked to liver dysfunction, metabolic and cardiovascular...

Liver enzyme levels (alanine transaminase)

Replicated

752839

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-02

Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.

Read RW, Schlauch KA et al.

Front Genet

Clinical conditions correlated with elevated triglyceride levels are well-known: coronary heart dise...

Triglyceride levels

Replicated

44504

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Diversity and scale: Genetic architecture of 2068 traits in the VA Million Veteran Program.

Verma A, Huffman JE et al.

Science

Takes medication for coronary artery/ coronary heart disease?

2024-07-19

Genome-wide association study implicates lipid pathway dysfunction in antipsychotic-induced weight gain: multi-ancestry validation.

Liao Y, Yu H et al.

Mol Psychiatry

Antipsychotic-induced HDL-cholesterol change in schizophrenia (4-week)

2024-02-09

Identification of a Common Variant for Coronary Heart Disease at PDE1A Contributes to Individualized Treatment Goals and Risk Stratification of Cardiovascular Complications in Chinese Patients With Type 2 Diabetes.

Tam CHT, Lim CKP et al.

Diabetes Care

Coronary heart disease in type 2 diabetes

2023-05-01

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Right ventricular end diastolic volume

2023-04-26

Circulating Soluble CD163, Associations With Cardiovascular Outcomes and Mortality, and Identification of Genetic Variants in Older Individuals: The Cardiovascular Health Study.

Durda P, Raffield LM et al.

J Am Heart Assoc

Soluble CD163 levels

2022-10-31

Validation of Polygenic Risk Scores for Coronary Heart Disease in a Middle Eastern Cohort Using Whole Genome Sequencing.

Saad M, El-Menyar A et al.

Circ Genom Precis Med

Coronary heart disease

2022-10-12

Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.

Dungan JR, Qin X et al.

Am Heart J Plus

Survival in coronary artery disease

2022-06-14

Genetic and observational evidence: No independent role for cholesterol efflux over static HDL concentration measures in CHD risk assessment.

Kuusisto S, Karjalainen MK et al.

J Intern Med

High-density lipoprotein mediated cholesterol efflux capacity

2022-03-15

The Pharmacogenetics of Statin Therapy on Clinical Events: No Evidence that Genetic Variation Affects Statin Response on Myocardial Infarction.

Trompet S, Postmus I et al.

Front Pharmacol

Myocardial infraction risk reduction in statin users

2022-01-05

Genome-Wide Association and Mendelian Randomization Analysis Reveal the Causal Relationship Between White Blood Cell Subtypes and Asthma in Africans.

Soremekun O, Soremekun C et al.

Front Genet

Monocyte count

2021-12-02

Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes.

Pazoki R, Vujkovic M et al.

Nat Commun

Liver enzyme levels (alanine transaminase)

2021-05-10

Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.

Read RW, Schlauch KA et al.

Front Genet

Triglyceride levels

2021-03-02