Active: Cortical thickness Clear all

GWAS 2024-06-18

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.

Zhukovsky P, Tio ES et al.

Nat Commun

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related...

Global cortical thickness (GlobalMeanMean)

34552

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-09

Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness.

Makowski C, Wang H et al.

Proc Natl Acad Sci U S A

Human cortical expansion has occurred non-uniformly across the brain. We assessed the genetic archit...

Dorsolateral prefrontal area (unadjusted for global measures)

Replicated

41624

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-15

The genetic architecture of human cortical folding.

van der Meer D, Kaufmann T et al.

Sci Adv

The folding of the human cerebral cortex is a highly genetically regulated process that allows for a...

Vertex-wise sulcal depth

33748

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-16

A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.

Park JY, Lee D et al.

Transl Psychiatry

Established genetic risk factors for Alzheimer's disease (AD) account for only a portion of AD herit...

Hippocampal volume

2643

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-21

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

Shadrin AA, Kaufmann T et al.

Neuroimage

Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability...

Cortical surface area

35657

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-03

Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.

Kim BH, Nho K et al.

Neurobiol Aging

To identify genetic variants influencing cortical atrophy in Alzheimer's disease (AD), we performed ...

Left inferior frontal gyrus (orbital part) cortical thickness

Replicated

1548

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-22

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Hofer E, Roshchupkin GV et al.

Nat Commun

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurologic...

Cortical surface area

Replicated

40980

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-09

Identification of Novel Genes Associated with Cortical Thickness in Alzheimer's Disease: Systems Biology Approach to Neuroimaging Endophenotype.

Kim BH, Choi YH et al.

J Alzheimers Dis

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by a heterogeneous dis...

Cortical thickness

919

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-01

The genetic architecture of the human cerebral cortex.

Grasby KL, Jahanshad N et al.

Science

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the spec...

Cortical thickness

Replicated

51662

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-11

Genetic control of variability in subcortical and intracranial volumes.

Córdova-Palomera A, van der Meer D et al.

Mol Psychiatry

Sensitivity to external demands is essential for adaptation to dynamic environments, but comes at th...

Brain imaging measurements (variance)

25575

Participants

N/A

Studies

Details PubMed

GWAS 2016-03-29

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

Roostaei T, Nazeri A et al.

Mol Psychiatry

The lack of strong association between brain beta-amyloid deposition and cognitive impairment has be...

Cognitive impairment (brain beta-amyloid deposition interaction)

Replicated

1627

Participants

N/A

Studies

Details PubMed

GWAS 2013-04-04

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.

Ran S, Pei YF et al.

PLoS One

Femoral neck geometric parameters (FNGPs), which include cortical thickness (CT), periosteal diamete...

Femoral neck bone geometry and menarche (age at onset)

Replicated

3055

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression.

Zhukovsky P, Tio ES et al.

Nat Commun

Global cortical thickness (GlobalMeanMean)

2024-06-18

Larger cerebral cortex is genetically correlated with greater frontal area and dorsal thickness.

Makowski C, Wang H et al.

Proc Natl Acad Sci U S A

Dorsolateral prefrontal area (unadjusted for global measures)

2023-03-09

The genetic architecture of human cortical folding.

van der Meer D, Kaufmann T et al.

Sci Adv

Vertex-wise sulcal depth

2021-12-15

A missense variant in SHARPIN mediates Alzheimer's disease-specific brain damages.

Park JY, Lee D et al.

Transl Psychiatry

Hippocampal volume

2021-11-16

Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology.

Shadrin AA, Kaufmann T et al.

Neuroimage

Cortical surface area

2021-09-21

Genome-wide association study identifies susceptibility loci of brain atrophy to NFIA and ST18 in Alzheimer's disease.

Kim BH, Nho K et al.

Neurobiol Aging

Left inferior frontal gyrus (orbital part) cortical thickness

2021-02-03

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22,824 adults.

Hofer E, Roshchupkin GV et al.

Nat Commun

Cortical surface area

2020-09-22

Identification of Novel Genes Associated with Cortical Thickness in Alzheimer's Disease: Systems Biology Approach to Neuroimaging Endophenotype.

Kim BH, Choi YH et al.

J Alzheimers Dis

Cortical thickness

2020-04-09

The genetic architecture of the human cerebral cortex.

Grasby KL, Jahanshad N et al.

Science

Cortical thickness

2020-03-01

Genetic control of variability in subcortical and intracranial volumes.

Córdova-Palomera A, van der Meer D et al.

Mol Psychiatry

Brain imaging measurements (variance)

2020-02-11

Genome-wide interaction study of brain beta-amyloid burden and cognitive impairment in Alzheimer's disease.

Roostaei T, Nazeri A et al.

Mol Psychiatry

Cognitive impairment (brain beta-amyloid deposition interaction)

2016-03-29

Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.

Ran S, Pei YF et al.

PLoS One

Femoral neck bone geometry and menarche (age at onset)

2013-04-04