Active: Endometriosis Clear all

GWAS 2025-04-22

The phenotypic and genetic association between endometriosis and immunological diseases.

Shigesi N, Harris HR et al.

Hum Reprod

Study question: Is there an increased risk of immunological diseases among endometriosis patients, a...

Ankylosing spondylitis

321025

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-14

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.

Venkatesh SS, Wittemans LBL et al.

Nat Genet

Genome-wide association studies (GWASs) may help inform the etiology of infertility. Here, we perfor...

Female infertility (anatomical)

675144

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-06

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk.

McGrath IM, Montgomery GW et al.

Hum Genet

Comorbid conditions can be driven by underlying pleiotropic and causal mechanisms that can provide i...

Endometriosis

281898

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-13

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A geno...

Endometriosis

474160

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-02

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertili...

Number of children ever born

Replicated

819971

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-01

Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.

Adewuyi EO, Mehta D et al.

Hum Reprod

Study question: Is there a shared genetic or causal association of endometriosis with asthma or what...

Endometriosis or asthma (pleiotropy)

610749

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-12

Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes.

Chou YC, Chen MJ et al.

Sci Rep

To determine whether genetic predisposition to endometriosis varies depending on ethnicity and in as...

Endometriosis

Replicated

430

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-27

A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese.

Masuda T, Ogawa K et al.

Cancer Sci

Causal inference is one of the challenges in epidemiologic studies. Gynecologic diseases have been r...

Ovarian cancer

40203

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-21

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Adewuyi EO, Mehta D et al.

Hum Genet

Evidence from observational studies indicates that endometriosis and depression often co-occur. Howe...

Endometriosis or depression (pleiotropy)

609867

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-17

Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.

Olafsdottir T, Thorleifsson G et al.

Commun Biol

Pelvic organ prolapse (POP) is a downward descent of one or more of the pelvic organs, resulting in ...

Pelvic organ prolapse

355744

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-29

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.

Adewuyi EO, Sapkota Y et al.

Genes (Basel)

Observational epidemiological studies indicate that endometriosis and migraine co-occur within indiv...

Endometriosis or migraine

411051

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-24

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Gallagher CS, Mäkinen N et al.

Nat Commun

Uterine leiomyomata (UL) are the most common neoplasms of the female reproductive tract and primary ...

Uterine fibroids and heavy menstrual bleeding

Replicated

202580

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The phenotypic and genetic association between endometriosis and immunological diseases.

Shigesi N, Harris HR et al.

Hum Reprod

Ankylosing spondylitis

2025-04-22

Genome-wide analyses identify 25 infertility loci and relationships with reproductive traits across the allele frequency spectrum.

Venkatesh SS, Wittemans LBL et al.

Nat Genet

Female infertility (anatomical)

2025-04-14

Genomic characterisation of the overlap of endometriosis with 76 comorbidities identifies pleiotropic and causal mechanisms underlying disease risk.

McGrath IM, Montgomery GW et al.

Hum Genet

Endometriosis

2023-07-06

The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions.

Rahmioglu N, Mortlock S et al.

Nat Genet

Endometriosis

2023-03-13

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Number of children ever born

2023-03-02

Genetic overlap analysis of endometriosis and asthma identifies shared loci implicating sex hormones and thyroid signalling pathways.

Adewuyi EO, Mehta D et al.

Hum Reprod

Endometriosis or asthma (pleiotropy)

2022-01-01

Integration of genome-wide association study and expression quantitative trait locus mapping for identification of endometriosis-associated genes.

Chou YC, Chen MJ et al.

Sci Rep

Endometriosis

2021-01-12

A Mendelian randomization study identified obesity as a causal risk factor of uterine endometrial cancer in Japanese.

Masuda T, Ogawa K et al.

Cancer Sci

Ovarian cancer

2020-09-27

Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality.

Adewuyi EO, Mehta D et al.

Hum Genet

Endometriosis or depression (pleiotropy)

2020-09-21

Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK Biobank.

Olafsdottir T, Thorleifsson G et al.

Commun Biol

Pelvic organ prolapse

2020-03-17

Shared Molecular Genetic Mechanisms Underlie Endometriosis and Migraine Comorbidity.

Adewuyi EO, Sapkota Y et al.

Genes (Basel)

Endometriosis or migraine

2020-02-29

Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.

Gallagher CS, Mäkinen N et al.

Nat Commun

Uterine fibroids and heavy menstrual bleeding

2019-10-24