Active: Glaucoma Clear all

GWAS 2024-02-01

Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.

Lo Faro V, Bhattacharya A et al.

Cell Rep Med

Primary open-angle glaucoma (POAG), a leading cause of irreversible blindness globally, shows dispar...

Glaucoma (primary open-angle)

1478037

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-01

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

Verma SS, Gudiseva HV et al.

Cell

Primary open-angle glaucoma (POAG), the leading cause of irreversible blindness worldwide, dispropor...

Primary open angle glaucoma

Replicated

54779

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-29

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.

Han X, Gharahkhani P et al.

Nat Genet

Glaucoma, a leading cause of irreversible blindness, is a highly heritable human disease. Previous g...

Primary open angle glaucoma (MTAG)

379422

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-14

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Yao X, Yang H et al.

Hum Genet

Age-related macular degeneration (AMD), cataract, and glaucoma are leading causes of blindness world...

AMD or cataract or glaucoma (pleiotropy)

818138

Participants

N/A

Studies

Details PubMed

GWAS 2022-11-30

Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

Gao XR, Chiariglione M et al.

Nat Commun

Elevated intraocular pressure (IOP) is a major risk factor for glaucoma, the leading cause of irreve...

Intraocular pressure

98674

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-03

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.

Praveen K, Patel GC et al.

Commun Biol

Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular ...

Intraocular pressure

129207

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-13

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.

Xue Z, Yuan J et al.

EBioMedicine

Ocular diseases may exhibit common clinical symptoms and epidemiological comorbidity. However, the e...

Age-related macular degeneration

66387

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-01

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.

Plotnikov D, Huang Y et al.

Invest Ophthalmol Vis Sci

Purpose: To test for causality with regard to the association between blood pressure (BP) and intrao...

Systolic blood pressure

526001

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-02

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.

Yang W, Li L et al.

Commun Biol

Metal elements are present in the human body, and their levels in the blood have important impacts o...

Plasma cadmium levels

656

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-12

Whole exome sequence analysis in 51 624 participants identifies novel genes and variants associated with refractive error and myopia.

Guggenheim JA, Clark R et al.

Hum Mol Genet

Refractive errors are associated with a range of pathological conditions, such as myopic maculopathy...

Refractive error

51624

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-11

GWAS identifies two common loci associated with pigment dispersion syndrome/pigmentary glaucoma and implicate myopia in its development.

Simcoe MJ, Shah A et al.

Ophthalmology

Purpose: To identify genetic variants associated with pigment dispersion syndrome (PDS) and pigmenta...

Pigment dispersion syndrome or pigmentary glaucoma

53201

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-09

Genome-Wide Polygenic Risk Score for Predicting High Risk Glaucoma Individuals of Han Chinese Ancestry.

Hsiao YJ, Chuang HK et al.

J Pers Med

Glaucoma is a progressive and irreversible blindness-causing disease. However, the underlying geneti...

Glaucoma

37575

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Novel ancestry-specific primary open-angle glaucoma loci and shared biology with vascular mechanisms and cell proliferation.

Lo Faro V, Bhattacharya A et al.

Cell Rep Med

Glaucoma (primary open-angle)

2024-02-01

A multi-cohort genome-wide association study in African ancestry individuals reveals risk loci for primary open-angle glaucoma.

Verma SS, Gudiseva HV et al.

Cell

Primary open angle glaucoma

2024-01-01

Large-scale multitrait genome-wide association analyses identify hundreds of glaucoma risk loci.

Han X, Gharahkhani P et al.

Nat Genet

Primary open angle glaucoma (MTAG)

2023-06-29

Genome-wide analysis of genetic pleiotropy and causal genes across three age-related ocular disorders.

Yao X, Yang H et al.

Hum Genet

AMD or cataract or glaucoma (pleiotropy)

2023-03-14

Whole-exome sequencing study identifies rare variants and genes associated with intraocular pressure and glaucoma.

Gao XR, Chiariglione M et al.

Nat Commun

Intraocular pressure

2022-11-30

ANGPTL7, a therapeutic target for increased intraocular pressure and glaucoma.

Praveen K, Patel GC et al.

Commun Biol

Intraocular pressure

2022-10-03

Genome-wide association meta-analysis of 88,250 individuals highlights pleiotropic mechanisms of five ocular diseases in UK Biobank.

Xue Z, Yuan J et al.

EBioMedicine

Age-related macular degeneration

2022-07-13

High Blood Pressure and Intraocular Pressure: A Mendelian Randomization Study.

Plotnikov D, Huang Y et al.

Invest Ophthalmol Vis Sci

Systolic blood pressure

2022-06-01

Genome-wide association and Mendelian randomization study of blood copper levels and 213 deep phenotypes in humans.

Yang W, Li L et al.

Commun Biol

Plasma cadmium levels

2022-05-02

Whole exome sequence analysis in 51 624 participants identifies novel genes and variants associated with refractive error and myopia.

Guggenheim JA, Clark R et al.

Hum Mol Genet

Refractive error

2022-01-12

GWAS identifies two common loci associated with pigment dispersion syndrome/pigmentary glaucoma and implicate myopia in its development.

Simcoe MJ, Shah A et al.

Ophthalmology

Pigment dispersion syndrome or pigmentary glaucoma

2022-01-11

Genome-Wide Polygenic Risk Score for Predicting High Risk Glaucoma Individuals of Han Chinese Ancestry.

Hsiao YJ, Chuang HK et al.

J Pers Med

Glaucoma

2021-11-09