Active: Glycemic traits Clear all

GWAS 2025-05-05

Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies.

Gu Y, Zheng H et al.

Nat Commun

Gestational diabetes mellitus, a heritable metabolic disorder and the most common pregnancy-related ...

Gestational diabetes mellitus

Replicated

97563

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-20

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Willems SM, Ng NHJ et al.

Wellcome Open Res

Genome-wide association studies for glycemic traits have identified hundreds of loci associated with...

Two-hour glucose

1784

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-07

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V, Jiang L et al.

Nat Genet

Conventional measurements of fasting and postprandial blood glucose levels investigated in genome-wi...

Random glucose levels

458862

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-08

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previ...

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

53287

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-20

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

The co-occurrence of migraine and glycemic traits has long been reported in observational epidemiolo...

Migraine or 2-hr glucose levels

937810

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-28

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.

DiCorpo D, Gaynor SM et al.

Commun Biol

The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly t...

Fasting glucose

26807

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-09

An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.

Riveros-Mckay F, Roberts D et al.

Diabetes

Fructosamine is a measure of short-term glycemic control, which has been suggested as a useful compl...

Fructosamine levels

Replicated

20731

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-31

The trans-ancestral genomic architecture of glycemic traits.

Chen J, Spracklen CN et al.

Nat Genet

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date...

Two-hour glucose

1431

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-30

Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study.

Buchanan VL, Wang Y et al.

Pediatr Obes

The genetic underpinnings of glycemic traits have been understudied in adolescent and Hispanic/Latin...

Fasting insulin

Replicated

44823

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-01

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

Gurdasani D, Carstensen T et al.

Cell

Genomic studies in African populations provide unique opportunities to understand disease etiology, ...

Eosinophil count

7526

Participants

N/A

Studies

Details PubMed

GWAS 2019-04-25

Pleiotropy informed adaptive association test of multiple traits using GWAS summary data.

Masotti M, Guo B et al.

Biometrics

Genetic variants associated with disease outcomes can be used to develop personalized treatment. To ...

Glycemic traits (pleiotropy)

46186

Participants

N/A

Studies

Details PubMed

GWAS 2018-04-05

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey.

Spracklen CN, Shi J et al.

PLoS Genet

To identify genetic contributions to type 2 diabetes (T2D) and related glycemic traits (fasting gluc...

Fasting blood glucose

5786

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic architecture and risk prediction of gestational diabetes mellitus in Chinese pregnancies.

Gu Y, Zheng H et al.

Nat Commun

Gestational diabetes mellitus

2025-05-05

Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.

Willems SM, Ng NHJ et al.

Wellcome Open Res

Two-hour glucose

2023-10-20

GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification.

Lagou V, Jiang L et al.

Nat Genet

Random glucose levels

2023-09-07

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

2023-06-08

Cross-trait analyses identify shared genetics between migraine, headache, and glycemic traits, and a causal relationship with fasting proinsulin.

Islam MR, Nyholt DR

Hum Genet

Migraine or 2-hr glucose levels

2023-02-20

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.

DiCorpo D, Gaynor SM et al.

Commun Biol

Fasting glucose

2022-07-28

An Expanded Genome-Wide Association Study of Fructosamine Levels Identifies RCN3 as a Replicating Locus and Implicates FCGRT as the Effector Transcript.

Riveros-Mckay F, Roberts D et al.

Diabetes

Fructosamine levels

2021-11-09

The trans-ancestral genomic architecture of glycemic traits.

Chen J, Spracklen CN et al.

Nat Genet

Two-hour glucose

2021-05-31

Genome-wide association study identifying novel variant for fasting insulin and allelic heterogeneity in known glycemic loci in Chilean adolescents: The Santiago Longitudinal Study.

Buchanan VL, Wang Y et al.

Pediatr Obes

Fasting insulin

2020-12-30

Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

Gurdasani D, Carstensen T et al.

Cell

Eosinophil count

2019-10-01

Pleiotropy informed adaptive association test of multiple traits using GWAS summary data.

Masotti M, Guo B et al.

Biometrics

Glycemic traits (pleiotropy)

2019-04-25

Identification and functional analysis of glycemic trait loci in the China Health and Nutrition Survey.

Spracklen CN, Shi J et al.

PLoS Genet

Fasting blood glucose

2018-04-05