Active: Gout Clear all

GWAS 2025-06-04

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

We addressed the underrepresentation of non-European populations in genome-wide association studies ...

Acute vascular insufficiency of intestine (PheCode 441.1)

228734

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-02

Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men.

Pagadala MS, Teerlink CC et al.

Nat Commun

Given the various roles of testosterone in men's health, we conducted a multi-ancestral genetic anal...

Total testosterone levels

95184

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-15

A genome-wide association analysis reveals new pathogenic pathways in gout.

Major TJ, Takei R et al.

Nat Genet

Gout is a chronic disease that is caused by an innate immune response to deposited monosodium urate ...

Gout

2728

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-25

Whole-genome sequencing reveals rare variants associated with gout in Taiwanese males.

Tseng YP, Chang YS et al.

Front Genet

To identify rare variants (RVs) of gout, we sequenced the whole genomes of 321 male gout patients an...

Gout (Window-based)

1021

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-24

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.

Cho C, Kim B et al.

Nat Commun

Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic dis...

Serum urate levels

1029323

Participants

N/A

Studies

Details PubMed

GWAS 2022-10-25

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.

Sumpter NA, Takei R et al.

Arthritis Rheumatol

Objective: To determine whether a gout polygenic risk score (PRS) is associated with age at gout ons...

Gout

332370

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-26

Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy number.

Pillalamarri V, Shi W et al.

HGG Adv

Inter-individual variation in the number of copies of the mitochondrial genome, called mitochondrial...

Mitochondrial DNA copy number

415422

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-27

Genetic contributions to female gout and hyperuricemia using genome-wide association study and polygenic risk score analyses.

Lin CY, Chang YS et al.

Rheumatology (Oxford)

Objectives: To identify genetic variants and polygenic risk score (PRS) relating to female gout and ...

Gout (age >=50)

19581

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-31

Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations.

Toyoda Y, Nakayama A et al.

Mol Genet Metab

Despite progress in understanding of the genetic basis of gout, the precise factors affecting differ...

Renal overload gout

1140

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-24

Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies.

Ko YL

Tzu Chi Med J

Gout is the most common form of inflammatory arthritis in adults. Elevation serum uric acid (SUA) co...

Serum uric acid levels

23067

Participants

N/A

Studies

Details PubMed

GWAS 2021-11-01

Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data.

Park JS, Kim Y et al.

J Hum Genet

The serum uric acid (SUA) level is an important determinant of gout, hypertension, metabolic syndrom...

Serum uric acid levels

60585

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-17

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Veturi Y, Lucas A et al.

Nat Genet

Plasma lipids are known heritable risk factors for cardiovascular disease, but increasing evidence a...

HDL cholesterol levels

31565

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Diversity and longitudinal records: Genetic architecture of disease associations and polygenic risk in the Taiwanese Han population.

Liu TY, Lu HF et al.

Sci Adv

Acute vascular insufficiency of intestine (PheCode 441.1)

2025-06-04

Discovery of novel ancestry specific genes for androgens and hypogonadism in Million Veteran Program Men.

Pagadala MS, Teerlink CC et al.

Nat Commun

Total testosterone levels

2025-05-02

A genome-wide association analysis reveals new pathogenic pathways in gout.

Major TJ, Takei R et al.

Nat Genet

Gout

2024-10-15

Whole-genome sequencing reveals rare variants associated with gout in Taiwanese males.

Tseng YP, Chang YS et al.

Front Genet

Gout (Window-based)

2024-09-25

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.

Cho C, Kim B et al.

Nat Commun

Serum urate levels

2024-04-24

Association of Gout Polygenic Risk Score with Age at Disease Onset and Tophaceous Disease in European and Polynesian Men with Gout.

Sumpter NA, Takei R et al.

Arthritis Rheumatol

Gout

2022-10-25

Whole-exome sequencing in 415,422 individuals identifies rare variants associated with mitochondrial DNA copy number.

Pillalamarri V, Shi W et al.

HGG Adv

Mitochondrial DNA copy number

2022-09-26

Genetic contributions to female gout and hyperuricemia using genome-wide association study and polygenic risk score analyses.

Lin CY, Chang YS et al.

Rheumatology (Oxford)

Gout (age >=50)

2022-06-27

Genome-wide meta-analysis between renal overload type and renal underexcretion type of clinically defined gout in Japanese populations.

Toyoda Y, Nakayama A et al.

Mol Genet Metab

Renal overload gout

2022-01-31

Genetics of hyperuricemia and gout: Insights from recent genome-wide association studies and Mendelian randomization studies.

Ko YL

Tzu Chi Med J

Serum uric acid levels

2021-11-24

Genome-wide meta-analysis revealed several genetic loci associated with serum uric acid levels in Korean population: an analysis of Korea Biobank data.

Park JS, Kim Y et al.

J Hum Genet

Serum uric acid levels

2021-11-01

A unified framework identifies new links between plasma lipids and diseases from electronic medical records across large-scale cohorts.

Veturi Y, Lucas A et al.

Nat Genet

HDL cholesterol levels

2021-06-17