Active: Heart failure Clear all

GWAS 2025-11-03

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.

Enzan N, Miyazawa K et al.

Nat Commun

To understand the genetic basis of heart failure (HF) in the Japanese population, we performed genom...

Heart failure

Replicated

1580320

Participants

N/A

Studies

Details PubMed

GWAS 2025-09-29

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

Jordà P, Lai Y et al.

NPJ Genom Med

Common genetic variation detected by genome-wide association studies (GWAS) partially explains varia...

Atrial fibrillation (MTAG)

296021

Participants

N/A

Studies

Details PubMed

GWAS 2025-04-07

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.

Lee DSM, Cardone KM et al.

Nat Genet

Heart failure is a complex trait, influenced by environmental and genetic factors, affecting over 30...

Heart failure

2358556

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-06

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.

Roselli C, Surakka I et al.

Nat Genet

Atrial fibrillation (AF) is the most common heart rhythm abnormality and is a leading cause of heart...

Atrial fibrillation

1650345

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-21

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy (DCM) is a heart muscle disease that represents an important cause of morbidi...

Dilated cardiomyopathy

Replicated

2404278

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-13

Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.

Koskeridis F, Fancy N et al.

Nat Commun

Several cardiovascular traits and diseases co-occur with Alzheimer's disease. We mapped their shared...

Alzheimer's disease (MTAG)

455258

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-24

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.

Cho C, Kim B et al.

Nat Commun

Hyperuricemia is an essential causal risk factor for gout and is associated with cardiometabolic dis...

Serum urate levels

1029323

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-02

Susceptibility of Atrial Fibrillation in Genetic Architecture and Heritability: A Genome-Wide Association Study in Taiwan.

Wu CI, Chen IC et al.

Heart Rhythm

No abstract available Keywords: Acute coronary syndrome; Atrial fibrillation; Genome-wide associatio...

Atrial fibrillation

10350

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-01

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

There is currently little evidence that the genetic basis of human phenotype varies significantly ac...

Age at natural menopause

Replicated

243506

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-10

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.

Rasooly D, Peloso GM et al.

Nat Commun

We conduct a large-scale meta-analysis of heart failure genome-wide association studies (GWAS) consi...

Heart failure

1266315

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-20

Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma.

Tantawy M, Yang G et al.

Front Cardiovasc Med

Proteasome inhibitor Carfilzomib (CFZ) is effective in treating patients with refractory or relapsed...

Cardiovascular adverse events in carfilzomib-treated multiple myeloma

228

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-26

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Dysfunction of either the right or left ventricle can lead to heart failure (HF) and subsequent morb...

Right ventricular end diastolic volume

35941

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population.

Enzan N, Miyazawa K et al.

Nat Commun

Heart failure

2025-11-03

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

Jordà P, Lai Y et al.

NPJ Genom Med

Atrial fibrillation (MTAG)

2025-09-29

Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.

Lee DSM, Cardone KM et al.

Nat Genet

Heart failure

2025-04-07

Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases.

Roselli C, Surakka I et al.

Nat Genet

Atrial fibrillation

2025-03-06

Genome-wide association study reveals mechanisms underlying dilated cardiomyopathy and myocardial resilience.

Jurgens SJ, Rämö JT et al.

Nat Genet

Dilated cardiomyopathy

2024-11-21

Multi-trait association analysis reveals shared genetic loci between Alzheimer's disease and cardiovascular traits.

Koskeridis F, Fancy N et al.

Nat Commun

Alzheimer's disease (MTAG)

2024-11-13

Large-scale cross-ancestry genome-wide meta-analysis of serum urate.

Cho C, Kim B et al.

Nat Commun

Serum urate levels

2024-04-24

Susceptibility of Atrial Fibrillation in Genetic Architecture and Heritability: A Genome-Wide Association Study in Taiwan.

Wu CI, Chen IC et al.

Heart Rhythm

Atrial fibrillation

2024-04-02

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

Age at natural menopause

2023-08-01

Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure.

Rasooly D, Peloso GM et al.

Nat Commun

Heart failure

2023-07-10

Whole-Exome sequencing analysis identified TMSB10/TRABD2A locus to be associated with carfilzomib-related cardiotoxicity among patients with multiple myeloma.

Tantawy M, Yang G et al.

Front Cardiovasc Med

Cardiovascular adverse events in carfilzomib-treated multiple myeloma

2023-06-20

Druggable proteins influencing cardiac structure and function: Implications for heart failure therapies and cancer cardiotoxicity.

Schmidt AF, Bourfiss M et al.

Sci Adv

Right ventricular end diastolic volume

2023-04-26