Active: Inflammatory bowel disease Clear all

GWAS 2025-01-01

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (IBD) with the two predominant endophenotypes-Crohn's disease (CD) and ul...

Inflammatory bowel disease (MTAG)

82967

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-11

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang C, Yang C et al.

Nat Genet

Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide asso...

Brain ceramide (d18:1/17:0, d17:1/18:0)* levels

611

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-22

Genetic insight into the relationship between inflammatory bowel disease and <i>Clostridioides difficile</i> infection.

Cushing-Damm KC, Chen Y et al.

mSphere

Patients with inflammatory bowel disease (IBD) are at increased risk of Clostridioides difficile inf...

Clostridioides difficle infection

677823

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-30

Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis.

Li M, Hao X et al.

Front Med

Although many susceptibility loci for IgA nephropathy (IgAN) have been identified, they only account...

IgA nephropathy

14033

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-27

Comprehensive association analyses of extraintestinal manifestations in inflammatory bowel disease.

Khrom M, Long M et al.

Gastroenterology

Background & aims: Patients with inflammatory bowel disease (IBD) frequently develop extraintest...

Extraintestinal manifestations in inflammatory bowel disease (ankylosing spondylitis and sacroiliitis)

12027

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-27

New genetic biomarkers predicting 5-aminosalicylate-induced adverse events in patients with inflammatory bowel diseases.

Park J, Park IS et al.

Therap Adv Gastroenterol

Notably, 5-aminosalicylates (5-ASA) are vital in treating inflammatory bowel diseases (IBD). The adv...

Response to 5-aminosalicylate in inflammatory bowel disease (mild adverse events)

311

Participants

N/A

Studies

Details PubMed

GWAS 2023-12-26

Genetic correlation, shared loci, but no causality between bipolar disorder and inflammatory bowel disease: A genome-wide pleiotropic analysis.

Wang BR, Wang J et al.

J Affect Disord

Background and aims: The comorbidity between bipolar disorder (BD) and inflammatory bowel disease (I...

Bipolar disorder or inflammatory bowel disease (MTAG)

473423

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-28

HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.

Zheng T, Roda G et al.

J Crohns Colitis

Background and aims: Microscopic colitis [MC] is currently regarded as an inflammatory bowel disease...

Microscopic colitis

554942

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-18

A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.

Akbari P, Vuckovic D et al.

Nat Commun

Blood cells contain functionally important intracellular structures, such as granules, critical to i...

Platelet side scatter

29675

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-10

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Circulating proteins have important functions in inflammation and a broad range of diseases. To iden...

Eukaryotic translation initiation factor 4E-binding protein 1 levels

Replicated

16321

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-01

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.

Khrom M, Li D et al.

Inflamm Bowel Dis

Sex is an integral variable often overlooked in complex disease genetics. Differences between sexes ...

Inflammatory bowel disease

33201

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-08

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with the foll...

Inflammatory bowel disease

398668

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Joint analysis of genome-wide cross-trait and multi-omics reveals molecular mechanisms of inflammatory bowel disease and nominates its novel therapeutic genes.

Zhu Z, Wei R et al.

FASEB J

Inflammatory bowel disease (MTAG)

2025-01-01

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang C, Yang C et al.

Nat Genet

Brain ceramide (d18:1/17:0, d17:1/18:0)* levels

2024-11-11

Genetic insight into the relationship between inflammatory bowel disease and <i>Clostridioides difficile</i> infection.

Cushing-Damm KC, Chen Y et al.

mSphere

Clostridioides difficle infection

2024-10-22

Identification of susceptibility loci and relevant cell type for IgA nephropathy in Han Chinese by integrative genome-wide analysis.

Li M, Hao X et al.

Front Med

IgA nephropathy

2024-09-30

Comprehensive association analyses of extraintestinal manifestations in inflammatory bowel disease.

Khrom M, Long M et al.

Gastroenterology

Extraintestinal manifestations in inflammatory bowel disease (ankylosing spondylitis and sacroiliitis)

2024-02-27

New genetic biomarkers predicting 5-aminosalicylate-induced adverse events in patients with inflammatory bowel diseases.

Park J, Park IS et al.

Therap Adv Gastroenterol

Response to 5-aminosalicylate in inflammatory bowel disease (mild adverse events)

2024-01-27

Genetic correlation, shared loci, but no causality between bipolar disorder and inflammatory bowel disease: A genome-wide pleiotropic analysis.

Wang BR, Wang J et al.

J Affect Disord

Bipolar disorder or inflammatory bowel disease (MTAG)

2023-12-26

HLA signatures as pathophysiological discriminants of microscopic colitis subtypes.

Zheng T, Roda G et al.

J Crohns Colitis

Microscopic colitis

2023-09-28

A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.

Akbari P, Vuckovic D et al.

Nat Commun

Platelet side scatter

2023-08-18

Genetics of circulating inflammatory proteins identifies drivers of immune-mediated disease risk and therapeutic targets.

Zhao JH, Stacey D et al.

Nat Immunol

Eukaryotic translation initiation factor 4E-binding protein 1 levels

2023-08-10

Sex-Dimorphic Analyses Identify Novel and Sex-Specific Genetic Associations in Inflammatory Bowel Disease.

Khrom M, Li D et al.

Inflamm Bowel Dis

Inflammatory bowel disease

2023-06-01

Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries.

Liu Z, Liu R et al.

Nat Genet

Inflammatory bowel disease

2023-05-08