Active: Insulin resistance Clear all

GWAS 2025-06-16

Differential Genetic Architecture of Insulin Resistance (HOMA-IR) Based on Obesity Status: Evidence from a Large-Scale GWAS of Koreans.

Choi JE, Kwon YJ et al.

Curr Issues Mol Biol

Insulin resistance (IR) is a key mechanism underlying type 2 diabetes mellitus and is closely associ...

Homeostasis model assessment of insulin resistance in normal weight

2635

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-01

Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Chebii VJ, Wade AN et al.

Diabetologia

Aims/hypothesis: Glycaemic traits such as high fasting glucose levels and insulin resistance are pos...

Fasting glucose adjusted for BMI

9989

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-14

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Insulin resistance causes multiple epidemic metabolic diseases, including type 2 diabetes, cardiovas...

Triglyceride to HDL cholesterol ratio

Replicated

419674

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-13

Genome-wide association study and polygenic score assessment of insulin resistance.

Aliyu U, Umlai UI et al.

Front Endocrinol (Lausanne)

Insulin resistance (IR) and beta cell dysfunction are the major drivers of type 2 diabetes (T2D). Ge...

Homeostasis model assessment of insulin resistance

Replicated

6217

Participants

N/A

Studies

Details PubMed

GWAS 2024-01-10

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Insulin resistance (IR) is a well-established risk factor for metabolic disease. The ratio of trigly...

Triglyceride to HDL cholesterol ratio

402398

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-18

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 d...

Adiponectin levels

Replicated

81993

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-02

Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids.

Naber A, Demus D et al.

Int J Mol Sci

Apolipoprotein-CIII (apo-CIII) is involved in triglyceride-rich lipoprotein metabolism and linked to...

Apo-CIII0c levels

2318

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-08

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previ...

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

53287

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-23

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

Mansour A, Mousa M et al.

Front Endocrinol (Lausanne)

Type 2 diabetes mellitus (T2DM) is a chronic, metabolic disorder in which concomitant insulin resist...

Diabetic retinopathy in type 2 diabetes

310

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-18

Association of polygenic risk scores for insulin resistance risk and their interaction with a plant-based diet, especially fruits, vitamin C, and flavonoid intake, in Asian adults.

Park S

Nutrition

Objectives: Insulin resistance is a common risk factor for metabolic syndrome (MetS), leading to typ...

Insulin resistance

58701

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-05

Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes.

Zhou W, Sun J et al.

Mol Psychiatry

Antipsychotic-induced metabolic syndrome (APs-induced Mets) is the most common adverse drug reaction...

Antipsychotic-induced metabolic syndrome in schizophrenia

939

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-16

Genome-wide association study of fasting proinsulin, fasting insulin, 2-hour postprandial proinsulin, and 2-hour postprandial insulin in Chinese Han people.

Lin L, Quan H et al.

Endokrynol Pol

Introduction: Fasting proinsulin (FPI) and fasting insulin (FI) have been demonstrated to be associa...

Fasting proinsulin levels in prediabetes

451

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Differential Genetic Architecture of Insulin Resistance (HOMA-IR) Based on Obesity Status: Evidence from a Large-Scale GWAS of Koreans.

Choi JE, Kwon YJ et al.

Curr Issues Mol Biol

Homeostasis model assessment of insulin resistance in normal weight

2025-06-16

Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Chebii VJ, Wade AN et al.

Diabetologia

Fasting glucose adjusted for BMI

2025-03-01

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

DeForest N, Wang Y et al.

Nat Commun

Triglyceride to HDL cholesterol ratio

2024-09-14

Genome-wide association study and polygenic score assessment of insulin resistance.

Aliyu U, Umlai UI et al.

Front Endocrinol (Lausanne)

Homeostasis model assessment of insulin resistance

2024-06-13

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

Oliveri A, Rebernick RJ et al.

Nat Genet

Triglyceride to HDL cholesterol ratio

2024-01-10

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Adiponectin levels

2023-10-18

Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids.

Naber A, Demus D et al.

Int J Mol Sci

Apo-CIII0c levels

2023-10-02

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Williamson A, Norris DM et al.

Nat Genet

Insulin fold change during an oral glucose tolerance test (adjusted for BMI)

2023-06-08

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

Mansour A, Mousa M et al.

Front Endocrinol (Lausanne)

Diabetic retinopathy in type 2 diabetes

2023-03-23

Association of polygenic risk scores for insulin resistance risk and their interaction with a plant-based diet, especially fruits, vitamin C, and flavonoid intake, in Asian adults.

Park S

Nutrition

Insulin resistance

2023-02-18

Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes.

Zhou W, Sun J et al.

Mol Psychiatry

Antipsychotic-induced metabolic syndrome in schizophrenia

2022-09-05

Genome-wide association study of fasting proinsulin, fasting insulin, 2-hour postprandial proinsulin, and 2-hour postprandial insulin in Chinese Han people.

Lin L, Quan H et al.

Endokrynol Pol

Fasting proinsulin levels in prediabetes

2022-08-16

Health & Traits Publications

Differential Genetic Architecture of Insulin Resistance (HOMA-IR) Based on Obesity Status: Evidence from a Large-Scale GWAS of Koreans.

Genome-wide association study identifying novel risk variants associated with glycaemic traits in the continental African AWI-Gen cohort.

Genome-wide discovery and integrative genomic characterization of insulin resistance loci using serum triglycerides to HDL-cholesterol ratio as a proxy.

Genome-wide association study and polygenic score assessment of insulin resistance.

Comprehensive genetic study of the insulin resistance marker TG:HDL-C in the UK Biobank.

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Apolipoprotein-CIII <i>O</i>-Glycosylation, a Link between <i>GALNT2</i> and Plasma Lipids.

Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.

Microvascular and macrovascular complications of type 2 diabetes mellitus: Exome wide association analyses.

Association of polygenic risk scores for insulin resistance risk and their interaction with a plant-based diet, especially fruits, vitamin C, and flavonoid intake, in Asian adults.

Multi-omics analysis identifies rare variation in leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to antipsychotics-induced metabolic syndromes.

Genome-wide association study of fasting proinsulin, fasting insulin, 2-hour postprandial proinsulin, and 2-hour postprandial insulin in Chinese Han people.