Active: LDL cholesterol levels Clear all

GWAS 2023-09-05

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

Deflaux N, Selvaraj MS et al.

Nat Commun

Recently, large scale genomic projects such as All of Us and the UK Biobank have introduced a new re...

LDL cholesterol levels

228736

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-08

Common and Rare <i>PCSK9</i> Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study.

Hsu LA, Teng MS et al.

Int J Mol Sci

PCSK9 is a candidate locus for low-density lipoprotein cholesterol (LDL-C) levels. The cause-effect ...

LDL cholesterol levels

75441

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-23

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

Circulating lipoprotein lipids cause coronary heart disease (CHD). However, the precise way in which...

LDL cholesterol levels

440546

Participants

N/A

Studies

Details PubMed

GWAS 2019-12-06

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metaboli...

LDL cholesterol levels x loop diuretics use interaction

38834

Participants

N/A

Studies

Details PubMed

GWAS 2019-11-12

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Noordam R, Bos MM et al.

Nat Commun

Both short and long sleep are associated with an adverse lipid profile, likely through different bio...

LDL cholesterol levels x short total sleep time interaction (2df test)

Replicated

111660

Participants

N/A

Studies

Details PubMed

GWAS 2019-05-31

Multiple rare and common variants in APOB gene locus associated with oxidatively modified low-density lipoprotein levels.

Khlebus E, Kutsenko V et al.

PLoS One

Oxidatively modified low-density lipoproteins (oxLDL) play an important role in the occurrence and p...

Oxidized LDL cholesterol levels

725

Participants

N/A

Studies

Details PubMed

GWAS 2019-05-13

Exome chip-driven association study of lipidemia in >14,000 Koreans and evaluation of genetic effect on identified variants between different ethnic groups.

Han S, Hwang MY et al.

Genet Epidemiol

Lipid levels in blood are widely used to diagnose and monitor chronic diseases. It is essential to i...

LDL cholesterol levels

13890

Participants

N/A

Studies

Details PubMed

GWAS 2015-12-22

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.

Tang CS, Zhang H et al.

Nat Commun

Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-...

LDL cholesterol levels

12685

Participants

N/A

Studies

Details PubMed

GWAS 2014-10-28

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Postmus I, Trompet S et al.

Nat Commun

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual r...

Response to statins (LDL cholesterol change)

Replicated

41875

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Demonstrating paths for unlocking the value of cloud genomics through cross cohort analysis.

Deflaux N, Selvaraj MS et al.

Nat Commun

LDL cholesterol levels

2023-09-05

Common and Rare <i>PCSK9</i> Variants Associated with Low-Density Lipoprotein Cholesterol Levels and the Risk of Diabetes Mellitus: A Mendelian Randomization Study.

Hsu LA, Teng MS et al.

Int J Mol Sci

LDL cholesterol levels

2022-09-08

Evaluating the relationship between circulating lipoprotein lipids and apolipoproteins with risk of coronary heart disease: A multivariable Mendelian randomisation analysis.

Richardson TG, Sanderson E et al.

PLoS Med

LDL cholesterol levels

2020-03-23

Genome-wide meta-analysis of variant-by-diuretic interactions as modulators of lipid traits in persons of European and African ancestry.

de las Fuentes L, Sung YJ et al.

Pharmacogenomics J

LDL cholesterol levels x loop diuretics use interaction

2019-12-06

Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration.

Noordam R, Bos MM et al.

Nat Commun

LDL cholesterol levels x short total sleep time interaction (2df test)

2019-11-12

Multiple rare and common variants in APOB gene locus associated with oxidatively modified low-density lipoprotein levels.

Khlebus E, Kutsenko V et al.

PLoS One

Oxidized LDL cholesterol levels

2019-05-31

Exome chip-driven association study of lipidemia in >14,000 Koreans and evaluation of genetic effect on identified variants between different ethnic groups.

Han S, Hwang MY et al.

Genet Epidemiol

LDL cholesterol levels

2019-05-13

Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese.

Tang CS, Zhang H et al.

Nat Commun

LDL cholesterol levels

2015-12-22

Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins.

Postmus I, Trompet S et al.

Nat Commun

Response to statins (LDL cholesterol change)

2014-10-28