Active: Lifespan Clear all

GWAS 2025-02-28

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Park J, Peña-Tauber A et al.

Nat Commun

Human lifespan is shaped by genetic and environmental factors. To enable precision health, understan...

Lifespan

393833

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-20

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Childhood maltreatment is increasingly recognized as a pivotal risk factor for adverse health outcom...

Physical neglect

129017

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-13

Genome-wide association study unravels mechanisms of brain glymphatic activity.

Huang SY, Ge YJ et al.

Nat Commun

Brain glymphatic activity, as indicated by diffusion-tensor imaging analysis along the perivascular ...

The diffusion-tensor imaging analysis along the perivascular space (ALPS) index in the left hemisphere

Replicated

44336

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-19

Genetic influences on circulating retinol and its relationship to human health.

Reay WR, Kiltschewskij DJ et al.

Nat Commun

Retinol is a fat-soluble vitamin that plays an essential role in many biological processes throughou...

Circulating retinol levels

Replicated

18903

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-07

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, ext...

Aging

1559001

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-01

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

There is currently little evidence that the genetic basis of human phenotype varies significantly ac...

Age at natural menopause

Replicated

243506

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-02

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Identifying genetic determinants of reproductive success may highlight mechanisms underlying fertili...

Number of children ever born

Replicated

819971

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-03

Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.

Akiyama M, Sakaue S et al.

Commun Biol

Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs...

Lifespan

78029

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-19

Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.

Hui D, Mehrabi S et al.

PLoS Genet

Loss or absence of hearing is common at both extremes of human lifespan, in the forms of congenital ...

Hearing loss

36507

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-24

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy a...

Increased healthspan in old age

2252

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-05

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are ...

Amygdala volume change rate

15100

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-02

The individual and global impact of copy-number variants on complex human traits.

Auwerx C, Lepamets M et al.

Am J Hum Genet

The impact of copy-number variations (CNVs) on complex human traits remains understudied. We called ...

Waist-hip ratio (UKB data field 49/48) (CNV mirror model)

330926

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes.

Park J, Peña-Tauber A et al.

Nat Commun

Lifespan

2025-02-28

Genetic architectures of childhood maltreatment and causal influence of childhood maltreatment on health outcomes in adulthood.

Chen TT, Chen CY et al.

Mol Psychiatry

Physical neglect

2025-02-20

Genome-wide association study unravels mechanisms of brain glymphatic activity.

Huang SY, Ge YJ et al.

Nat Commun

The diffusion-tensor imaging analysis along the perivascular space (ALPS) index in the left hemisphere

2025-01-13

Genetic influences on circulating retinol and its relationship to human health.

Reay WR, Kiltschewskij DJ et al.

Nat Commun

Circulating retinol levels

2024-02-19

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

Aging

2023-08-07

Genetic insights into the age-specific biological mechanisms governing human ovarian aging.

Ojavee SE, Darrous L et al.

Am J Hum Genet

Age at natural menopause

2023-08-01

Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus.

Mathieson I, Day FR et al.

Nat Hum Behav

Number of children ever born

2023-03-02

Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals.

Akiyama M, Sakaue S et al.

Commun Biol

Lifespan

2023-02-03

Gene burden analysis identifies genes associated with increased risk and severity of adult-onset hearing loss in a diverse hospital-based cohort.

Hui D, Mehrabi S et al.

PLoS Genet

Hearing loss

2023-01-19

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

Increased healthspan in old age

2022-06-24

Genetic variants associated with longitudinal changes in brain structure across the lifespan.

Brouwer RM, Klein M et al.

Nat Neurosci

Amygdala volume change rate

2022-04-05

The individual and global impact of copy-number variants on complex human traits.

Auwerx C, Lepamets M et al.

Am J Hum Genet

Waist-hip ratio (UKB data field 49/48) (CNV mirror model)

2022-03-02