Active: Longevity Clear all

GWAS 2024-01-16

A genome-wide association study of social trust in 33,882 Danish blood donors.

Sequeros CB, Hansen TF et al.

Sci Rep

Social trust is a heritable trait that has been linked with physical health and longevity. In this s...

Social trust (item 1)

25908

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-07

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

The concept of aging is complex, including many related phenotypes such as healthspan, lifespan, ext...

Aging

1559001

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-24

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

To find drivers of healthy ageing, a genome-wide association study (GWAS) was performed in healthy a...

Increased healthspan in old age

2252

Participants

N/A

Studies

Details PubMed

GWAS 2022-04-14

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.

Xu Q, Wu C et al.

Nat Aging

A better understanding of the biological and environmental variables that contribute to exceptional ...

1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4) levels (advanced age)

116

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-02

The individual and global impact of copy-number variants on complex human traits.

Auwerx C, Lepamets M et al.

Am J Hum Genet

The impact of copy-number variations (CNVs) on complex human traits remains understudied. We called ...

Waist-hip ratio (UKB data field 49/48) (CNV mirror model)

330926

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-04

Genetic insights into biological mechanisms governing human ovarian ageing.

Ruth KS, Day FR et al.

Nature

Reproductive longevity is essential for fertility and influences healthy ageing in women1,2, but ins...

Age at natural menopause

Replicated

574468

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-01

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Mills MC, Tropf FC et al.

Nat Hum Behav

Age at first sexual intercourse and age at first birth have implications for health and evolutionary...

Age at first sexual intercourse

214547

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-04

Effect of longevity genetic variants on the molecular aging rate.

Gurinovich A, Song Z et al.

Geroscience

We conducted a genome-wide association study of 1320 centenarians from the New England Centenarian S...

Longevity (100 years and older)

Replicated

5169

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-03

Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.

Liu X, Song Z et al.

Aging Cell

There is growing interest in studying the genetic contributions to longevity, but limited relevant g...

Longevity

11045

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-16

Genome-wide association analysis of cognitive function in Danish long-lived individuals.

Nygaard M, Dowsett J et al.

Mech Ageing Dev

Cognitive function is a substantially heritable trait related to numerous important life outcomes. S...

Cognitive function in longevity

490

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-25

Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes.

Torres GG, Nygaard M et al.

J Gerontol A Biol Sci Med Sci

Despite enormous research efforts, the genetic component of longevity has remained largely elusive. ...

Longevity

Replicated

13023

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-07

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.

Demange PA, Malanchini M et al.

Nat Genet

Little is known about the genetic architecture of traits affecting educational attainment other than...

Noncognitive aspects of educational attainment

510795

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A genome-wide association study of social trust in 33,882 Danish blood donors.

Sequeros CB, Hansen TF et al.

Sci Rep

Social trust (item 1)

2024-01-16

Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging.

Rosoff DB, Mavromatis LA et al.

Nat Aging

Aging

2023-08-07

Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study.

Saul N, Dhondt I et al.

Biogerontology

Increased healthspan in old age

2022-06-24

Metagenomic and metabolomic remodeling in nonagenarians and centenarians and its association with genetic and socioeconomic factors.

Xu Q, Wu C et al.

Nat Aging

1-(1-enyl-palmitoyl)-2-arachidonoyl-gpc (p-16:0/20:4) levels (advanced age)

2022-04-14

The individual and global impact of copy-number variants on complex human traits.

Auwerx C, Lepamets M et al.

Am J Hum Genet

Waist-hip ratio (UKB data field 49/48) (CNV mirror model)

2022-03-02

Genetic insights into biological mechanisms governing human ovarian ageing.

Ruth KS, Day FR et al.

Nature

Age at natural menopause

2021-08-04

Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour.

Mills MC, Tropf FC et al.

Nat Hum Behav

Age at first sexual intercourse

2021-07-01

Effect of longevity genetic variants on the molecular aging rate.

Gurinovich A, Song Z et al.

Geroscience

Longevity (100 years and older)

2021-05-04

Integrated genetic analyses revealed novel human longevity loci and reduced risks of multiple diseases in a cohort study of 15,651 Chinese individuals.

Liu X, Song Z et al.

Aging Cell

Longevity

2021-03-03

Genome-wide association analysis of cognitive function in Danish long-lived individuals.

Nygaard M, Dowsett J et al.

Mech Ageing Dev

Cognitive function in longevity

2021-02-16

Exome-wide association study identifies FN3KRP and PGP as new candidate longevity genes.

Torres GG, Nygaard M et al.

J Gerontol A Biol Sci Med Sci

Longevity

2021-01-25

Investigating the genetic architecture of noncognitive skills using GWAS-by-subtraction.

Demange PA, Malanchini M et al.

Nat Genet

Noncognitive aspects of educational attainment

2021-01-07