Active: Metabolite levels Clear all

GWAS 2025-02-28

Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.

Reus LM, Boltz T et al.

Mol Psychiatry

Genomic studies of molecular traits have provided mechanistic insights into complex disease, though ...

Cerebrospinal fluid unidentified metabolite levels (Lipidomics ID: 4.81_704.57)

977

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-11

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang C, Yang C et al.

Nat Genet

Brain metabolism perturbation can contribute to traits and diseases. We conducted a genome-wide asso...

Brain ceramide (d18:1/17:0, d17:1/18:0)* levels

611

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-30

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.

Feofanova EV, Brown MR et al.

Nat Commun

Circulating metabolite levels may reflect the state of the human organism in health and disease, how...

Metabolite levels (N-acetylserine)

Replicated

29825

Participants

N/A

Studies

Details PubMed

GWAS 2022-12-08

Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort.

Lee IH, Smith MR et al.

Hum Genomics

The human exposome is composed of diverse metabolites and small chemical compounds originated from e...

Plasma metabolome feature (c18_403)

441

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-11

Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.

Hysi PG, Mangino M et al.

Metabolites

Metabolites are small products of metabolism that provide a snapshot of the wellbeing of an organism...

1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) levels

8809

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-07

Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension.

Luo S, Feofanova EV et al.

Kidney Int

The genome-wide association study (GWAS) is a powerful means to study genetic determinants of diseas...

Serum metabolite concentrations in chronic kidney disease

619

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-05

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors.

Calvo-Serra B, Maitre L et al.

Hum Mol Genet

Human metabolism is influenced by genetic and environmental factors. Previous studies have identifie...

2-hydroxyisobutyrate levels

996

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-11

A reference map of potential determinants for the human serum metabolome.

Bar N, Korem T et al.

Nature

The serum metabolome contains a plethora of biomarkers and causative agents of various diseases, som...

X-21792 levels

1170

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-01

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

Feofanova EV, Chen H et al.

Am J Hum Genet

Variation in levels of the human metabolome reflect changes in homeostasis, providing a window into ...

Serum metabolite levels

Replicated

5435

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-10

Matrix metalloproteinase-degraded type I collagen is associated with APOE/TOMM40 variants and preclinical dementia.

Tang ME, Blair JPM et al.

Neurol Genet

Objective: Dysregulation of type I collagen metabolism has a great impact on human health. We have p...

Serum type 1 collagen metabolite levels

4891

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-09

The influence of rare variants in circulating metabolic biomarkers.

Riveros-Mckay F, Oliver-Williams C et al.

PLoS Genet

Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, asso...

Triglyceride levels in large HDL

7142

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-21

Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.

Nag A, Kurushima Y et al.

Hum Mol Genet

Saliva, as a biofluid, is inexpensive and non-invasive to obtain, and provides a vital tool to inves...

Salivary metabolite levels

Replicated

2419

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Quantitative trait loci mapping of circulating metabolites in cerebrospinal fluid to uncover biological mechanisms involved in brain-related phenotypes.

Reus LM, Boltz T et al.

Mol Psychiatry

Cerebrospinal fluid unidentified metabolite levels (Lipidomics ID: 4.81_704.57)

2025-02-28

Genetic architecture of cerebrospinal fluid and brain metabolite levels and the genetic colocalization of metabolites with human traits.

Wang C, Yang C et al.

Nat Genet

Brain ceramide (d18:1/17:0, d17:1/18:0)* levels

2024-11-11

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.

Feofanova EV, Brown MR et al.

Nat Commun

Metabolite levels (N-acetylserine)

2023-05-30

Comprehensive characterization of putative genetic influences on plasma metabolome in a pediatric cohort.

Lee IH, Smith MR et al.

Hum Genomics

Plasma metabolome feature (c18_403)

2022-12-08

Metabolome Genome-Wide Association Study Identifies 74 Novel Genomic Regions Influencing Plasma Metabolites Levels.

Hysi PG, Mangino M et al.

Metabolites

1-stearoyl-2-arachidonoyl-GPE (18:0/20:4) levels

2022-01-11

Genome-wide association study of serum metabolites in the African American Study of Kidney Disease and Hypertension.

Luo S, Feofanova EV et al.

Kidney Int

Serum metabolite concentrations in chronic kidney disease

2021-04-07

Urinary metabolite quantitative trait loci in children and their interaction with dietary factors.

Calvo-Serra B, Maitre L et al.

Hum Mol Genet

2-hydroxyisobutyrate levels

2020-12-05

A reference map of potential determinants for the human serum metabolome.

Bar N, Korem T et al.

Nature

X-21792 levels

2020-11-11

A Genome-wide Association Study Discovers 46 Loci of the Human Metabolome in the Hispanic Community Health Study/Study of Latinos.

Feofanova EV, Chen H et al.

Am J Hum Genet

Serum metabolite levels

2020-10-01

Matrix metalloproteinase-degraded type I collagen is associated with APOE/TOMM40 variants and preclinical dementia.

Tang ME, Blair JPM et al.

Neurol Genet

Serum type 1 collagen metabolite levels

2020-09-10

The influence of rare variants in circulating metabolic biomarkers.

Riveros-Mckay F, Oliver-Williams C et al.

PLoS Genet

Triglyceride levels in large HDL

2020-03-09

Genome-wide scan identifies novel genetic loci regulating salivary metabolite levels.

Nag A, Kurushima Y et al.

Hum Mol Genet

Salivary metabolite levels

2020-01-21