Active: Ovarian cancer Clear all

GWAS 2025-11-20

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.

Barnes DR, Tyrer JP et al.

NPJ Genom Med

Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta...

High-grade serous ovarian cancer

120248

Participants

N/A

Studies

Details PubMed

GWAS 2025-08-29

Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study.

Güler M, Canzian F

Blood Cancer J

Lymphoid neoplasms (LNs) are heterogeneous malignancies arising from lymphoid cells, displaying dive...

Lymphoid neoplasms (B-cell phenocluster)

Replicated

1118280

Participants

N/A

Studies

Details PubMed

GWAS 2025-07-01

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Fat distribution patterns are increasingly linked to obesity-related cancers; however, their shared ...

Leg fat ratio or ovarian cancer (pleiotropy)

127582

Participants

N/A

Studies

Details PubMed

GWAS 2025-03-07

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.

Wilcox N, Tyrer JP et al.

Am J Hum Genet

Genome-wide association studies have been highly successful at identifying common variants associate...

Pancreatic cancer (Gene-based burden)

419307

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-07

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

Dareng EO, Coetzee SG et al.

Am J Hum Genet

To identify credible causal risk variants (CCVs) associated with different histotypes of epithelial ...

Non-mucinous epithelial ovarian cancer

129118

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-05

Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.

Ramachandran D, Tyrer JP et al.

NPJ Genom Med

Survival from ovarian cancer depends on the resection status after primary surgery. We performed gen...

Macroscopic residual disease after surgery in ovarian cancer (FIGO stage adjusted)

7111

Participants

N/A

Studies

Details PubMed

GWAS 2023-07-29

A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers.

Zhao X, Wu X et al.

iScience

Little is known regarding the long-term adverse effects of COVID-19 on female-specific cancers, nor ...

Breast cancer or COVID-19 infection (pleiotropy)

2845029

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-20

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.

Sato G, Shirai Y et al.

Nat Commun

Integrating genomic data of multiple cancers allows de novo cancer grouping and elucidating the shar...

Ovarian cancer

Replicated

336340

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-03

A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers.

Guo H, Cao W et al.

Front Microbiol

Breast, ovarian, prostate, lung, and head/neck cancers are five solid cancers with complex interrela...

Breast cancer or ovarian cancer (pleiotropy)

295401

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-14

Polygenic risk modeling for prediction of epithelial ovarian cancer risk.

Dareng EO, Tyrer JP et al.

Eur J Hum Genet

Polygenic risk scores (PRS) for epithelial ovarian cancer (EOC) have the potential to improve risk s...

Non-mucinous epithelial ovarian cancer

63702

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-21

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women.

Dai H, Chu X et al.

Cell Discov

Ovarian cancer survival varies considerably among patients, to which germline variation may also con...

Overall survival in ovarian cancer

Replicated

2130

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-05

Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens.

Quintanilha JCF, Wang J et al.

Int J Cancer

Germline variants might predict cancer progression. Bevacizumab improves overall survival (OS) in pa...

Overall survival in cancer

Replicated

1686

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.

Barnes DR, Tyrer JP et al.

NPJ Genom Med

High-grade serous ovarian cancer

2025-11-20

Clustering of lymphoid neoplasms by cell of origin, somatic mutation and drug usage profiles: a multi-trait genome-wide association study.

Güler M, Canzian F

Blood Cancer J

Lymphoid neoplasms (B-cell phenocluster)

2025-08-29

Investigating the shared genetic architecture between adiposity measures and obesity-related cancers.

Wang S, Liu H et al.

Brief Bioinform

Leg fat ratio or ovarian cancer (pleiotropy)

2025-07-01

The contribution of coding variants to the heritability of multiple cancer types using UK Biobank whole-exome sequencing data.

Wilcox N, Tyrer JP et al.

Am J Hum Genet

Pancreatic cancer (Gene-based burden)

2025-03-07

Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.

Dareng EO, Coetzee SG et al.

Am J Hum Genet

Non-mucinous epithelial ovarian cancer

2024-05-07

Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.

Ramachandran D, Tyrer JP et al.

NPJ Genom Med

Macroscopic residual disease after surgery in ovarian cancer (FIGO stage adjusted)

2024-03-05

A large-scale genome-wide cross-trait analysis for the effect of COVID-19 on female-specific cancers.

Zhao X, Wu X et al.

iScience

Breast cancer or COVID-19 infection (pleiotropy)

2023-07-29

Pan-cancer and cross-population genome-wide association studies dissect shared genetic backgrounds underlying carcinogenesis.

Sato G, Shirai Y et al.

Nat Commun

Ovarian cancer

2023-06-20

A genome-wide cross-cancer meta-analysis highlights the shared genetic links of five solid cancers.

Guo H, Cao W et al.

Front Microbiol

Breast cancer or ovarian cancer (pleiotropy)

2023-02-03

Polygenic risk modeling for prediction of epithelial ovarian cancer risk.

Dareng EO, Tyrer JP et al.

Eur J Hum Genet

Non-mucinous epithelial ovarian cancer

2022-01-14

Genome-wide association and functional interrogation identified a variant at 3p26.1 modulating ovarian cancer survival among Chinese women.

Dai H, Chu X et al.

Cell Discov

Overall survival in ovarian cancer

2021-12-21

Genome-wide association studies of survival in 1520 cancer patients treated with bevacizumab-containing regimens.

Quintanilha JCF, Wang J et al.

Int J Cancer

Overall survival in cancer

2021-10-05