Active: Platelet aggregation Clear all

GWAS 2022-03-21

Secondary analyses for genome-wide association studies using expression quantitative trait loci.

Ngwa JS, Yanek LR et al.

Genet Epidemiol

Genome-wide association studies (GWAS) have successfully identified thousands of single nucleotide p...

Platelet aggregation

806

Participants

N/A

Studies

Details PubMed

GWAS 2020-07-04

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling.

Rodriguez BAT, Bhan A et al.

Am J Hum Genet

Dual antiplatelet therapy reduces ischemic events in cardiovascular disease, but it increases bleedi...

Thrombin-induced platelet aggregation

1184

Participants

N/A

Studies

Details PubMed

GWAS 2017-11-29

Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.

Chen MH, Yanek LR et al.

Platelets

Previous genome-wide association studies (GWAS) have identified several variants associated with pla...

Platelet aggregation

Replicated

6010

Participants

N/A

Studies

Details PubMed

GWAS 2017-04-01

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Backman JD, O'Connell JR et al.

Pharmacogenet Genomics

Clopidogrel is one of the most commonly used therapeutics for the secondary prevention of cardiovasc...

Clopidogrel active metabolite levels

513

Participants

N/A

Studies

Details PubMed

GWAS 2015-05-30

Genome-wide association study of platelet aggregation in African Americans.

Qayyum R, Becker LC et al.

BMC Genet

We have previously shown that platelet aggregation has higher heritability in African Americans than...

Platelet aggregation

Replicated

2165

Participants

N/A

Studies

Details PubMed

GWAS 2013-03-18

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).

Zhou G, Marathe GK et al.

J Biol Chem

Aspirin is rapidly hydrolyzed within erythrocytes by a heterodimer of PAFAH1b2/PAFAH1b3 but also in ...

Aspirin hydrolysis (plasma)

2054

Participants

N/A

Studies

Details PubMed

GWAS 2013-02-07

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.

Lewis JP, Ryan K et al.

Circ Cardiovasc Genet

BACKGROUND- Aspirin or dual antiplatelet therapy with aspirin and clopidogrel is a standard therapy ...

Response to antiplatelet therapy

Replicated

1792

Participants

N/A

Studies

Details PubMed

GWAS 2012-03-08

A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

Qayyum R, Snively BM et al.

PLoS Genet

Several genetic variants associated with platelet count and mean platelet volume (MPV) were recently...

Mean platelet volume

16388

Participants

N/A

Studies

Details PubMed

GWAS 2010-06-06

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

Johnson AD, Yanek LR et al.

Nat Genet

Platelet function mediates both beneficial and harmful effects on human health, but few genes are kn...

Platelet aggregation

Replicated

4831

Participants

N/A

Studies

Details PubMed

GWAS 2009-04-01

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

Danik JS, Paré G et al.

Circ Cardiovasc Genet

Fibrinogen is a multifunctional circulating glycoprotein involved in wound healing, thrombosis, plat...

Fibrinogen

17686

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Secondary analyses for genome-wide association studies using expression quantitative trait loci.

Ngwa JS, Yanek LR et al.

Genet Epidemiol

Platelet aggregation

2022-03-21

A Platelet Function Modulator of Thrombin Activation Is Causally Linked to Cardiovascular Disease and Affects PAR4 Receptor Signaling.

Rodriguez BAT, Bhan A et al.

Am J Hum Genet

Thrombin-induced platelet aggregation

2020-07-04

Exome-chip meta-analysis identifies association between variation in ANKRD26 and platelet aggregation.

Chen MH, Yanek LR et al.

Platelets

Platelet aggregation

2017-11-29

Genome-wide analysis of clopidogrel active metabolite levels identifies novel variants that influence antiplatelet response.

Backman JD, O'Connell JR et al.

Pharmacogenet Genomics

Clopidogrel active metabolite levels

2017-04-01

Genome-wide association study of platelet aggregation in African Americans.

Qayyum R, Becker LC et al.

BMC Genet

Platelet aggregation

2015-05-30

Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).

Zhou G, Marathe GK et al.

J Biol Chem

Aspirin hydrolysis (plasma)

2013-03-18

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.

Lewis JP, Ryan K et al.

Circ Cardiovasc Genet

Response to antiplatelet therapy

2013-02-07

A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

Qayyum R, Snively BM et al.

PLoS Genet

Mean platelet volume

2012-03-08

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.

Johnson AD, Yanek LR et al.

Nat Genet

Platelet aggregation

2010-06-06

Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.

Danik JS, Paré G et al.

Circ Cardiovasc Genet

Fibrinogen

2009-04-01