Active: Platelet count Clear all

GWAS 2023-12-08

Genetic Basis of Altered Platelet Counts and Gestational Thrombocytopenia in Pregnancy.

Yang Z, Hu L et al.

Blood

Platelet count reduction occurs throughout pregnancy, with 5% to 12% of pregnant women being diagnos...

Platelet count during second trimester of pregnancy

72816

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-14

<i>PIK3R3</i> is a candidate regulator of platelet count in people of Bangladeshi ancestry.

Burley K, Fitzgibbon L et al.

Res Pract Thromb Haemost

Blood platelets are mediators of atherothrombotic disease and are regulated by complex sets of genes...

Platelet count

20218

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-06

A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer's and Parkinson's Disease.

Tirozzi A, Quiccione MS et al.

Cells

Among candidate neurodegenerative/neuropsychiatric risk-predictive biomarkers, platelet count, mean ...

Alzheimer disease (MTAG)

455258

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-06

Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative.

Little A, Hu Y et al.

Hum Mol Genet

Platelets play a key role in thrombosis and hemostasis. Platelet count (PLT) and mean platelet volum...

Platelet count

Replicated

97702

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-01

An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.

Sun P, Zhou W et al.

Hum Mol Genet

Genomic discovery efforts for hematological traits have been successfully conducted through genome-w...

Neutrophil granulocyte count

Replicated

9084

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-19

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study.

Hsu LA, Chou HH et al.

Atherosclerosis

Background and aims: Platelet count (PLT) is a predictor of metabolic and inflammation-related disor...

Platelet count

17037

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-30

Multivariate Genome-Wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.

Nath AP, Ritchie SC et al.

Am J Hum Genet

Cytokines are essential regulatory components of the immune system, and their aberrant levels have b...

Cytokine levels

9263

Participants

N/A

Studies

Details PubMed

GWAS 2019-06-13

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort.

Read RW, Schlauch KA et al.

PLoS One

In this study, we perform a full genome-wide association study (GWAS) to identify statistically sign...

Mean platelet volume

4675

Participants

N/A

Studies

Details PubMed

GWAS 2018-11-19

The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans.

Tunjungputri RN, Li Y et al.

Thromb Haemost

Inflammation and coagulation are key processes in cardiovascular diseases (CVDs). The Canakinumab An...

Platelet count and reactivity phenotypes

534

Participants

N/A

Studies

Details PubMed

GWAS 2018-06-22

Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.

Witten A, Bolbrinker J et al.

J Mol Med (Berl)

Immune-mediated heparin-induced thrombocytopenia (HIT) is the clinically most important adverse drug...

Heparin-induced thrombocytopenia

Replicated

364

Participants

N/A

Studies

Details PubMed

GWAS 2017-11-01

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.

Lin BD, Carnero-Montoro E et al.

J Hum Genet

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are important biomarkers...

Platelet-to-lymphocyte ratio

Replicated

8439

Participants

N/A

Studies

Details PubMed

GWAS 2016-11-01

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

Iotchkova V, Huang J et al.

Nat Genet

Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation ...

Cardiometabolic and hematological traits

Replicated

138486

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genetic Basis of Altered Platelet Counts and Gestational Thrombocytopenia in Pregnancy.

Yang Z, Hu L et al.

Blood

Platelet count during second trimester of pregnancy

2023-12-08

<i>PIK3R3</i> is a candidate regulator of platelet count in people of Bangladeshi ancestry.

Burley K, Fitzgibbon L et al.

Res Pract Thromb Haemost

Platelet count

2023-05-14

A Multi-Trait Association Analysis of Brain Disorders and Platelet Traits Identifies Novel Susceptibility Loci for Major Depression, Alzheimer's and Parkinson's Disease.

Tirozzi A, Quiccione MS et al.

Cells

Alzheimer disease (MTAG)

2023-01-06

Whole genome sequence analysis of platelet traits in the NHLBI trans-omics for precision medicine initiative.

Little A, Hu Y et al.

Hum Mol Genet

Platelet count

2021-09-06

An Asian-specific MPL genetic variant alters JAK-STAT signaling and influences platelet count in the population.

Sun P, Zhou W et al.

Hum Mol Genet

Neutrophil granulocyte count

2021-05-01

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study.

Hsu LA, Chou HH et al.

Atherosclerosis

Platelet count

2021-01-19

Multivariate Genome-Wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.

Nath AP, Ritchie SC et al.

Am J Hum Genet

Cytokine levels

2019-10-30

GWAS and PheWAS of red blood cell components in a Northern Nevadan cohort.

Read RW, Schlauch KA et al.

PLoS One

Mean platelet volume

2019-06-13

The Inter-Relationship of Platelets with Interleukin-1β-Mediated Inflammation in Humans.

Tunjungputri RN, Li Y et al.

Thromb Haemost

Platelet count and reactivity phenotypes

2018-11-19

Targeted resequencing of a locus for heparin-induced thrombocytopenia on chromosome 5 identified in a genome-wide association study.

Witten A, Bolbrinker J et al.

J Mol Med (Berl)

Heparin-induced thrombocytopenia

2018-06-22

2SNP heritability and effects of genetic variants for neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio.

Lin BD, Carnero-Montoro E et al.

J Hum Genet

Platelet-to-lymphocyte ratio

2017-11-01

Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

Iotchkova V, Huang J et al.

Nat Genet

Cardiometabolic and hematological traits

2016-11-01