Active: Psoriasis Clear all

GWAS 2025-08-19

Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.

Sonehara K, Watanabe R et al.

Cell Genom

Psoriasis vulgaris (PsV) is an immune-mediated inflammatory skin disorder with complex genetic archi...

Psoriasis vulgaris

5383

Participants

N/A

Studies

Details PubMed

GWAS 2025-02-28

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Dand N, Stuart PE et al.

Nat Commun

Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified bi...

Psoriasis

494544

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-30

Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.

Zhang M, Su W et al.

J Transl Med

Psoriasis is a common chronic, recurrent, immune-mediated disease involved in the skin or joints or ...

Psoriasis

472819

Participants

N/A

Studies

Details PubMed

GWAS 2024-11-01

Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.

Liu S, Li L et al.

Brief Bioinform

Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy...

Psoriasis

863080

Participants

N/A

Studies

Details PubMed

GWAS 2024-06-21

Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis.

Wang Q, Wu Y et al.

Arch Dermatol Res

Psoriasis and insomnia have co-morbidities, however, their common genetic basis is still unclear. We...

Insomnia or psoriasis (pleiotropy)

679093

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-28

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

Hernandez-Cordero A, Thomas L et al.

J Allergy Clin Immunol

Palmoplantar pustulosis (PPP) is an inflammatory skin disorder that mostly affects smokers and manif...

Palmoplantar pustulosis

403506

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-17

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan.

Yang JS, Liu TY et al.

Mol Med Rep

Psoriasis is a chronic inflammatory dermatological disease, and there is a lack of understanding of ...

Psoriasis

69688

Participants

N/A

Studies

Details PubMed

GWAS 2024-05-17

GENETIC STUDY OF PSORIASIS HIGHLIGHTS ITS CLOSE LINK WITH SOCIO-ECONOMIC STATUS AND AFFECTIVE SYMPTOMS.

Heikkilä A, Sliz E et al.

J Invest Dermatol

Psoriasis is an inflammatory skin disease with an estimated heritability of around 70%. Previous GWA...

Psoriasis

925649

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Response to the anti-IL17 monoclonal antibody secukinumab is heterogeneous, and not all participants...

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

754

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-16

Identification of the BTN3A3 gene as a molecule implicated in generalized pustular psoriasis in a Chinese population.

Zhang Q, Shi P et al.

J Invest Dermatol

The discovery of pathogenic variants provided biological insight into the role of host genetic facto...

Generalized pustular psoriasis

Replicated

685

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-15

Atopic polygenic risk score is associated with paradoxical eczema developing in psoriasis patients treated with biologics.

Al-Janabi A, Eyre S et al.

J Invest Dermatol

Biologic therapies for psoriasis can cause paradoxical eczema. The role of genetic factors in its pa...

Paradoxical eczema in biologic-treated plaque psoriasis

3212

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-18

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.

Saarentaus EC, Karjalainen J et al.

Nat Commun

Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases of the si...

Pharyngeal disease

Replicated

232365

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene.

Sonehara K, Watanabe R et al.

Cell Genom

Psoriasis vulgaris

2025-08-19

GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets.

Dand N, Stuart PE et al.

Nat Commun

Psoriasis

2025-02-28

Multi-ancestry genome-wide meta-analysis with 472,819 individuals identifies 32 novel risk loci for psoriasis.

Zhang M, Su W et al.

J Transl Med

Psoriasis

2025-01-30

Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.

Liu S, Li L et al.

Brief Bioinform

Psoriasis

2024-11-01

Genomic correlation, shared loci, and causal relationship between insomnia and psoriasis: a large-scale genome-wide cross-trait analysis.

Wang Q, Wu Y et al.

Arch Dermatol Res

Insomnia or psoriasis (pleiotropy)

2024-06-21

A genome-wide meta-analysis of palmoplantar pustulosis implicates Th2 responses and cigarette smoking in disease pathogenesis.

Hernandez-Cordero A, Thomas L et al.

J Allergy Clin Immunol

Palmoplantar pustulosis

2024-05-28

Genome‑wide association study and polygenic risk scores predict psoriasis and its shared phenotypes in Taiwan.

Yang JS, Liu TY et al.

Mol Med Rep

Psoriasis

2024-05-17

GENETIC STUDY OF PSORIASIS HIGHLIGHTS ITS CLOSE LINK WITH SOCIO-ECONOMIC STATUS AND AFFECTIVE SYMPTOMS.

Heikkilä A, Sliz E et al.

J Invest Dermatol

Psoriasis

2024-05-17

Response to anti-IL17 therapy in inflammatory disease is not strongly impacted by genetic background.

Zhang C, Shestopaloff K et al.

Am J Hum Genet

Erythrocyte sedimentation rate x secukinumab treatment interaction in ankylosing spondylitis

2023-08-24

Identification of the BTN3A3 gene as a molecule implicated in generalized pustular psoriasis in a Chinese population.

Zhang Q, Shi P et al.

J Invest Dermatol

Generalized pustular psoriasis

2023-02-16

Atopic polygenic risk score is associated with paradoxical eczema developing in psoriasis patients treated with biologics.

Al-Janabi A, Eyre S et al.

J Invest Dermatol

Paradoxical eczema in biologic-treated plaque psoriasis

2023-02-15

Inflammatory and infectious upper respiratory diseases associate with 41 genomic loci and type 2 inflammation.

Saarentaus EC, Karjalainen J et al.

Nat Commun

Pharyngeal disease

2023-01-18