Active: Pulmonary function Clear all

GWAS 2024-03-12

Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.

Seo J, Gaddis NC et al.

Am J Clin Nutr

Higher 25-hydroxyvitamin D (25(OH)D) concentrations in serum has a positive association with pulmona...

FEV1 x serum 25-hydroxyvitamin D interaction in never smokers (2df test)

115312

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-18

Association of biological age with health outcomes and its modifiable factors.

Liu WS, You J et al.

Aging Cell

Identifying the clinical implications and modifiable and unmodifiable factors of aging requires the ...

Biological age gap

9008

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-14

A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank.

Sinkala M, Elsheikh SSM et al.

Commun Biol

Pulmonary function is an indicator of well-being, and pulmonary pathologies are the third major caus...

FEV1

5978

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-18

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Pulmonary function (PF) progressively declines with aging. Forced expiratory volume in the first sec...

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

6229

Participants

N/A

Studies

Details PubMed

GWAS 2020-09-29

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Bronchodilator (BD) drugs are commonly prescribed for treatment and management of obstructive lung f...

Lung function (FVC) in asthma

104

Participants

N/A

Studies

Details PubMed

GWAS 2019-09-19

Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.

Freitag-Wolf S, Munz M et al.

J Dent Res

Periodontitis has low-prevalence, highly severe disease manifestations with an early onset and rapid...

Early onset periodontitis x smoking status interaction

741

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-29

Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).

Sakornsakolpat P, McCormack M et al.

Am J Respir Cell Mol Biol

DlCO is a widely used pulmonary function test in clinical practice and a particularly useful measure...

Diffusing capacity of carbon monoxide

6935

Participants

N/A

Studies

Details PubMed

GWAS 2018-09-10

Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.

Xu J, Gaddis NC et al.

Am J Respir Crit Care Med

Rationale: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory properties that co...

Pulmonary function (FEV1) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)

Replicated

13649

Participants

N/A

Studies

Details PubMed

GWAS 2018-07-30

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Wyss AB, Sofer T et al.

Nat Commun

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of Europe...

Lung function (FEV1)

90715

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-02

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

Burkart KM, Sofer T et al.

Am J Respir Crit Care Med

Rationale: Lung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Geno...

FEV1

Replicated

111472

Participants

N/A

Studies

Details PubMed

GWAS 2015-12-03

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Lutz SM, Cho MH et al.

BMC Genet

Pulmonary function decline is a major contributor to morbidity and mortality among smokers. Post bro...

Post bronchodilator FEV1 in COPD

6260

Participants

N/A

Studies

Details PubMed

GWAS 2014-11-01

Genetic variants associated with lung function: the long life family study.

Thyagarajan B, Wojczynski M et al.

Respir Res

Reduced forced expiratory volume in 1 second (FEV1) and the ratio of FEV1 to forced vital capacity (...

Pulmonary function

Replicated

52090

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Exploiting meta-analysis of genome-wide interaction with serum 25-hydroxyvitamin D to identify novel genetic loci associated with pulmonary function.

Seo J, Gaddis NC et al.

Am J Clin Nutr

FEV1 x serum 25-hydroxyvitamin D interaction in never smokers (2df test)

2024-03-12

Association of biological age with health outcomes and its modifiable factors.

Liu WS, You J et al.

Aging Cell

Biological age gap

2023-09-18

A genome-wide association study identifies distinct variants associated with pulmonary function among European and African ancestries from the UK Biobank.

Sinkala M, Elsheikh SSM et al.

Commun Biol

FEV1

2023-01-14

Genetic pleiotropy between pulmonary function and age-related traits: The Long Life Family Study.

Feitosa MF, Wojczynski MK et al.

J Gerontol A Biol Sci Med Sci

Forced vital capacity and interleukin-6 levels and high-sensitivity C-reactive protein levels (pleiotropy)

2022-02-18

Integrative genomic analysis in African American children with asthma finds three novel loci associated with lung function.

Goddard PC, Keys KL et al.

Genet Epidemiol

Lung function (FVC) in asthma

2020-09-29

Smoking Modifies the Genetic Risk for Early-Onset Periodontitis.

Freitag-Wolf S, Munz M et al.

J Dent Res

Early onset periodontitis x smoking status interaction

2019-09-19

Genome-Wide Association Analysis of Single Breath Diffusing Capacity of Carbon Monoxide (DLCO).

Sakornsakolpat P, McCormack M et al.

Am J Respir Cell Mol Biol

Diffusing capacity of carbon monoxide

2019-01-29

Omega-3 Fatty Acids and Genome-wide Interaction Analyses Reveal DPP10-Pulmonary Function Association.

Xu J, Gaddis NC et al.

Am J Respir Crit Care Med

Pulmonary function (FEV1) x omega-3 PUFA (docosapentaenoic acid) interaction (2df)

2018-09-10

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.

Wyss AB, Sofer T et al.

Nat Commun

Lung function (FEV1)

2018-07-30

A Genome-wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.

Burkart KM, Sofer T et al.

Am J Respir Crit Care Med

FEV1

2018-02-02

A genome-wide association study identifies risk loci for spirometric measures among smokers of European and African ancestry.

Lutz SM, Cho MH et al.

BMC Genet

Post bronchodilator FEV1 in COPD

2015-12-03

Genetic variants associated with lung function: the long life family study.

Thyagarajan B, Wojczynski M et al.

Respir Res

Pulmonary function

2014-11-01