Active: Response to statin therapy Clear all

GWAS 2020-01-16

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

In pharmacogenomic studies of quantitative change, any association between genetic variants and the ...

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

1205

Participants

N/A

Studies

Details PubMed

GWAS 2014-04-26

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

Postmus I, Johnson PC et al.

Atherosclerosis

Statin therapy is widely used in the prevention and treatment of cardiovascular events and is associ...

Cardiovascular event reduction in the elderly at risk for vascular disease (statin therapy interaction)

Replicated

6477

Participants

N/A

Studies

Details PubMed

GWAS 2012-11-01

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

Chu AY, Guilianini F et al.

Circ Cardiovasc Genet

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is a proinflammatory enzyme bound to low-densi...

Lipoprotein-associated phospholipase A2 activity change in response to statin therapy

Replicated

5329

Participants

N/A

Studies

Details PubMed

GWAS 2012-10-24

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

Hopewell JC, Parish S et al.

Eur Heart J

Aims: Statins reduce LDL cholesterol (LDL-C) and the risk of vascular events, but it remains uncerta...

Response to statin therapy

Replicated

18705

Participants

N/A

Studies

Details PubMed

GWAS 2012-05-30

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

Shiffman D, Trompet S et al.

PLoS One

Statin therapy reduces the risk of coronary heart disease (CHD), however, the person-to-person varia...

Coronary heart disease event reduction (statin therapy interaction)

Replicated

13784

Participants

N/A

Studies

Details PubMed

GWAS 2012-02-24

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).

Deshmukh HA, Colhoun HM et al.

J Lipid Res

We carried out a genome-wide association study (GWAS) of LDL-c response to statin using data from pa...

Response to statin therapy

Replicated

5252

Participants

N/A

Studies

Details PubMed

GWAS 2011-08-08

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS.

Isackson PJ, Ochs-Balcom HM et al.

Muscle Nerve

Introduction: Of the nearly 38 million people in the USA who receive statin therapy, 0.1-0.5% experi...

Response to statin therapy

Replicated

188

Participants

N/A

Studies

Details PubMed

GWAS 2010-03-22

Genome-wide association of lipid-lowering response to statins in combined study populations.

Barber MJ, Mangravite LM et al.

PLoS One

Statins effectively lower total and plasma LDL-cholesterol, but the magnitude of decrease varies amo...

Response to statin therapy

3928

Participants

N/A

Studies

Details PubMed

GWAS 2009-04-01

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.

Thompson JF, Hyde CL et al.

Circ Cardiovasc Genet

Statins are effective at lowering low-density lipoprotein cholesterol and reducing risk of cardiovas...

Response to statin therapy

Replicated

6993

Participants

N/A

Studies

Details PubMed

GWAS 2008-07-23

SLCO1B1 variants and statin-induced myopathy--a genomewide study.

Link E, Parish S et al.

N Engl J Med

Lowering low-density lipoprotein cholesterol with statin therapy results in substantial reductions i...

Response to statin therapy

Replicated

16839

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

2020-01-16

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

Postmus I, Johnson PC et al.

Atherosclerosis

Cardiovascular event reduction in the elderly at risk for vascular disease (statin therapy interaction)

2014-04-26

Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.

Chu AY, Guilianini F et al.

Circ Cardiovasc Genet

Lipoprotein-associated phospholipase A2 activity change in response to statin therapy

2012-11-01

Impact of common genetic variation on response to simvastatin therapy among 18 705 participants in the Heart Protection Study.

Hopewell JC, Parish S et al.

Eur Heart J

Response to statin therapy

2012-10-24

Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

Shiffman D, Trompet S et al.

PLoS One

Coronary heart disease event reduction (statin therapy interaction)

2012-05-30

Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).

Deshmukh HA, Colhoun HM et al.

J Lipid Res

Response to statin therapy

2012-02-24

Association of common variants in the human eyes shut ortholog (EYS) with statin-induced myopathy: evidence for additional functions of EYS.

Isackson PJ, Ochs-Balcom HM et al.

Muscle Nerve

Response to statin therapy

2011-08-08

Genome-wide association of lipid-lowering response to statins in combined study populations.

Barber MJ, Mangravite LM et al.

PLoS One

Response to statin therapy

2010-03-22

Comprehensive whole-genome and candidate gene analysis for response to statin therapy in the Treating to New Targets (TNT) cohort.

Thompson JF, Hyde CL et al.

Circ Cardiovasc Genet

Response to statin therapy

2009-04-01

SLCO1B1 variants and statin-induced myopathy--a genomewide study.

Link E, Parish S et al.

N Engl J Med

Response to statin therapy

2008-07-23