Active: Smoking behavior Clear all

GWAS 2024-10-04

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer remains the leading cause of cancer mortality, despite declining smoking rates. Previous...

Lung cancer

Replicated

260154

Participants

N/A

Studies

Details PubMed

GWAS 2023-04-25

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.

Andreu-Sánchez S, Bourgonje AR et al.

Immunity

Phage-displayed immunoprecipitation sequencing (PhIP-seq) has enabled high-throughput profiling of h...

Seropositivity for staphylococcus aureus peptide (agilent_234840)

1745

Participants

N/A

Studies

Details PubMed

GWAS 2022-08-01

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.

Byun J, Han Y et al.

Nat Genet

To identify new susceptibility loci to lung cancer among diverse populations, we performed cross-anc...

Lung cancer

Replicated

1008284

Participants

N/A

Studies

Details PubMed

GWAS 2022-05-02

Genetic analysis of lung cancer and the germline impact on somatic mutation burden.

Gabriel AAG, Atkins JR et al.

J Natl Cancer Inst

Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide asso...

Lung cancer or family history of lung cancer

329946

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-09

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.

Li Y, Xiao X et al.

Hum Mol Genet

Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully e...

lung cancer x sex interaction

24223

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-14

White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy.

Ye Z, Mo C et al.

Front Neurosci

Tobacco smoking is an addictive behavior that supports nicotine dependence and is an independent ris...

Smoking behavior

293759

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-01

Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies.

Wu Y, Zhong X et al.

Proc Natl Acad Sci U S A

Marginal effect estimates in genome-wide association studies (GWAS) are mixtures of direct and indir...

Educational attainment (direct effects)

24434

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-18

Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium.

Peterson RE, Bigdeli TB et al.

J Psychiatr Res

While 17% of US adults use tobacco regularly, smoking rates among persons with schizophrenia are upw...

smoking initiation in schizophrenia

Replicated

7057

Participants

N/A

Studies

Details PubMed

GWAS 2020-10-20

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.

Xu K, Li B et al.

Nat Commun

Here we report a large genome-wide association study (GWAS) for longitudinal smoking phenotypes in 2...

Smoking status (current vs mixed)

202116

Participants

N/A

Studies

Details PubMed

GWAS 2020-03-10

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Smoking behaviors, including amount smoked, smoking cessation, and tobacco-related diseases, are alt...

Nicotine metabolite ratio in current smokers

5185

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-13

Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.

Hällfors J, Palviainen T et al.

Addict Biol

The heritability of nicotine dependence based on family studies is substantial. Nevertheless, knowle...

Smoking behaviour (cigarettes smoked per day)

Replicated

9059

Participants

N/A

Studies

Details PubMed

GWAS 2018-02-15

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Sung YJ, Winkler TW et al.

Am J Hum Genet

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor ...

Systolic blood pressure x smoking status (current vs non-current) interaction (1df test)

Replicated

604624

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Multi-ancestry GWAS meta-analyses of lung cancer reveal susceptibility loci and elucidate smoking-independent genetic risk.

Gorman BR, Ji SG et al.

Nat Commun

Lung cancer

2024-10-04

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire.

Andreu-Sánchez S, Bourgonje AR et al.

Immunity

Seropositivity for staphylococcus aureus peptide (agilent_234840)

2023-04-25

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer.

Byun J, Han Y et al.

Nat Genet

Lung cancer

2022-08-01

Genetic analysis of lung cancer and the germline impact on somatic mutation burden.

Gabriel AAG, Atkins JR et al.

J Natl Cancer Inst

Lung cancer or family history of lung cancer

2022-05-02

Genome-wide interaction analysis identified low-frequency variants with sex disparity in lung cancer risk.

Li Y, Xiao X et al.

Hum Mol Genet

lung cancer x sex interaction

2022-02-09

White Matter Integrity and Nicotine Dependence: Evaluating Vertical and Horizontal Pleiotropy.

Ye Z, Mo C et al.

Front Neurosci

Smoking behavior

2021-10-14

Estimating genetic nurture with summary statistics of multigenerational genome-wide association studies.

Wu Y, Zhong X et al.

Proc Natl Acad Sci U S A

Educational attainment (direct effects)

2021-06-01

Genome-wide analyses of smoking behaviors in schizophrenia: Findings from the Psychiatric Genomics Consortium.

Peterson RE, Bigdeli TB et al.

J Psychiatr Res

smoking initiation in schizophrenia

2021-02-18

Genome-wide association study of smoking trajectory and meta-analysis of smoking status in 842,000 individuals.

Xu K, Li B et al.

Nat Commun

Smoking status (current vs mixed)

2020-10-20

Genome-wide association meta-analysis of nicotine metabolism and cigarette consumption measures in smokers of European descent.

Buchwald J, Chenoweth MJ et al.

Mol Psychiatry

Nicotine metabolite ratio in current smokers

2020-03-10

Genome-wide association study in Finnish twins highlights the connection between nicotine addiction and neurotrophin signaling pathway.

Hällfors J, Palviainen T et al.

Addict Biol

Smoking behaviour (cigarettes smoked per day)

2018-03-13

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Sung YJ, Winkler TW et al.

Am J Hum Genet

Systolic blood pressure x smoking status (current vs non-current) interaction (1df test)

2018-02-15