Active: Substance use disorder Clear all

GWAS 2025-10-07

Genome-wide meta-analyses of cross substance use disorders in diverse populations.

Lai D, Zhang M et al.

Mol Psychiatry

Substance use disorders (SUDs, including alcohol, cannabis, opioids, and tobacco) represent signific...

Substance use disorder

240296

Participants

N/A

Studies

Details PubMed

GWAS 2024-04-17

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

Toikumo S, Jennings MV et al.

Nat Hum Behav

Tobacco use disorder (TUD) is the most prevalent substance use disorder in the world. Genetic factor...

Tobacco use disorder

898680

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-01

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Chronic pain is a common problem, with more than one-fifth of adult Americans reporting pain daily o...

Pain intensity (without opioid use disorder)

416740

Participants

N/A

Studies

Details PubMed

GWAS 2023-11-30

Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.

LaBianca S, Brikell I et al.

Nat Genet

Attention deficit hyperactivity disorder (ADHD) is a complex disorder that manifests variability in ...

Attention deficit hyperactivity disorder (first diagnosed in adulthood vs childhood)

14084

Participants

N/A

Studies

Details PubMed

GWAS 2023-03-22

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

Hatoum AS, Colbert SMC et al.

Nat Ment Health

Genetic liability to substance use disorders can be parsed into loci that confer general or substanc...

Addiction risk factors

647703

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-28

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Despite an estimated heritability of ~50%, genome-wide association studies of opioid use disorder (O...

Opioid use disorder

447521

Participants

N/A

Studies

Details PubMed

GWAS 2022-07-25

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Deak JD, Zhou H et al.

Mol Psychiatry

Despite the large toll of opioid use disorder (OUD), genome-wide association studies (GWAS) of OUD t...

Opioid use disorder

554186

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-11

Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data.

Meng P, Ye J et al.

Transl Psychiatry

It is well-accepted that both environment and genetic factors contribute to the development of menta...

Mental disorders (time to event)

376806

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-29

Genome-wide association study of stimulant dependence.

Cox J, Sherva R et al.

Transl Psychiatry

Stimulant dependence is heritable, but specific genetic factors underlying the trait have not been i...

Stimulant dependence

Replicated

22416

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-28

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.

Sherva R, Zhu C et al.

Explor Med

Aim: Substance use disorders (SUD) result in substantial morbidity and mortality worldwide. Opioids,...

Cocaine dependence (time to event)

Replicated

11026

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-31

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.

Alblooshi H, Al Safar H et al.

BMC Psychiatry

Genome Wide Association Studies (GWAS) have been conducted to identify genes and pathways involved i...

Opioid use disorder

452

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-09

Genome-Wide Association Study of Opioid Cessation.

Cox JW, Sherva RM et al.

J Clin Med

The United States is experiencing an epidemic of opioid use disorder (OUD) and overdose-related deat...

Opioid use cessation

4049

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide meta-analyses of cross substance use disorders in diverse populations.

Lai D, Zhang M et al.

Mol Psychiatry

Substance use disorder

2025-10-07

Multi-ancestry meta-analysis of tobacco use disorder identifies 461 potential risk genes and reveals associations with multiple health outcomes.

Toikumo S, Jennings MV et al.

Nat Hum Behav

Tobacco use disorder

2024-04-17

A multi-ancestry genetic study of pain intensity in 598,339 veterans.

Toikumo S, Vickers-Smith R et al.

Nat Med

Pain intensity (without opioid use disorder)

2024-03-01

Polygenic profiles define aspects of clinical heterogeneity in attention deficit hyperactivity disorder.

LaBianca S, Brikell I et al.

Nat Genet

Attention deficit hyperactivity disorder (first diagnosed in adulthood vs childhood)

2023-11-30

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders.

Hatoum AS, Colbert SMC et al.

Nat Ment Health

Addiction risk factors

2023-03-22

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects in brain regions associated with addiction.

Kember RL, Vickers-Smith R et al.

Nat Neurosci

Opioid use disorder

2022-09-28

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci.

Deak JD, Zhou H et al.

Mol Psychiatry

Opioid use disorder

2022-07-25

Associations between genetic loci, environment factors and mental disorders: a genome-wide survival analysis using the UK Biobank data.

Meng P, Ye J et al.

Transl Psychiatry

Mental disorders (time to event)

2022-01-11

Genome-wide association study of stimulant dependence.

Cox J, Sherva R et al.

Transl Psychiatry

Stimulant dependence

2021-06-29

Genome-wide association study of phenotypes measuring progression from first cocaine or opioid use to dependence reveals novel risk genes.

Sherva R, Zhu C et al.

Explor Med

Cocaine dependence (time to event)

2021-02-28

Stratified analyses of genome wide association study data reveal haplotypes for a candidate gene on chromosome 2 (KIAA1211L) is associated with opioid use in patients of Arabian descent.

Alblooshi H, Al Safar H et al.

BMC Psychiatry

Opioid use disorder

2020-01-31

Genome-Wide Association Study of Opioid Cessation.

Cox JW, Sherva RM et al.

J Clin Med

Opioid use cessation

2020-01-09