Active: Sudden cardiac death Clear all

GWAS 2023-06-15

A Genome-Wide Analysis of a Sudden Cardiac Death Cohort: Identifying Novel Target Variants in the Era of Molecular Autopsy.

Beccacece L, Abondio P et al.

Genes (Basel)

Sudden cardiac death (SCD) is an unexpected natural death due to cardiac causes, usually happening w...

Sudden cardiac death

Participants

N/A

Studies

Details PubMed

GWAS 2022-09-01

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Young WJ, Lahrouchi N et al.

Nat Commun

The QT interval is an electrocardiographic measure representing the sum of ventricular depolarizatio...

QT interval

252730

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-28

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.

Choi SH, Jurgens SJ et al.

Circ Genom Precis Med

Alterations in electrocardiographic (ECG) intervals are well-known markers for arrhythmia and sudden...

RR interval

Replicated

27967

Participants

N/A

Studies

Details PubMed

GWAS 2021-04-22

Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Young WJ, Warren HR et al.

Circ Genom Precis Med

ECG markers of ventricular depolarization and repolarization are associated with an increased risk o...

Calcium levels

305349

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-20

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.

Lahrouchi N, Tadros R et al.

Circulation

Long QT syndrome (LQTS) is a rare genetic disorder and a major preventable cause of sudden cardiac d...

Long QT syndrome

11492

Participants

N/A

Studies

Details PubMed

GWAS 2020-05-06

Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection.

Turley TN, O'Byrne MM et al.

JAMA Cardiol

Importance: Spontaneous coronary artery dissection (SCAD), an idiopathic disorder that predominantly...

Spontaneous coronary artery dissection

Replicated

2484

Participants

N/A

Studies

Details PubMed

GWAS 2020-04-29

Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval.

Ramírez J, van Duijvenboden S et al.

Am J Hum Genet

Sudden cardiac death is responsible for half of all deaths from cardiovascular disease. The analysis...

TPE interval (resting)

71338

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-10

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.

Teumer A, Trenkwalder T et al.

JCI Insight

BACKGROUNDThe presence of an early repolarization pattern (ERP) on the surface ECG is associated wit...

Early cardiac repolarization

39456

Participants

N/A

Studies

Details PubMed

GWAS 2018-07-17

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Prins BP, Mead TJ et al.

Genome Biol

Genome-wide association studies conducted on QRS duration, an electrocardiographic measurement assoc...

QRS duration

Replicated

197467

Participants

N/A

Studies

Details PubMed

GWAS 2018-04-05

Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).

Tereshchenko LG, Sotoodehnia N et al.

J Am Heart Assoc

ECG global electrical heterogeneity (GEH) is associated with sudden cardiac death. We hypothesized t...

Global electrical heterogeneity phenotypes

13826

Participants

N/A

Studies

Details PubMed

GWAS 2014-07-17

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

Hong KW, Lim JE et al.

Hum Mol Genet

The electrocardiogram has several advantages in detecting cardiac arrhythmia-it is readily available...

PR interval

Replicated

13380

Participants

N/A

Studies

Details PubMed

GWAS 2014-06-22

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Arking DE, Pulit SL et al.

Nat Genet

The QT interval, an electrocardiographic measure reflecting myocardial repolarization, is a heritabl...

QT interval

Replicated

104377

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A Genome-Wide Analysis of a Sudden Cardiac Death Cohort: Identifying Novel Target Variants in the Era of Molecular Autopsy.

Beccacece L, Abondio P et al.

Genes (Basel)

Sudden cardiac death

2023-06-15

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways.

Young WJ, Lahrouchi N et al.

Nat Commun

QT interval

2022-09-01

Rare Coding Variants Associated With Electrocardiographic Intervals Identify Monogenic Arrhythmia Susceptibility Genes: A Multi-Ancestry Analysis.

Choi SH, Jurgens SJ et al.

Circ Genom Precis Med

RR interval

2021-07-28

Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Young WJ, Warren HR et al.

Circ Genom Precis Med

Calcium levels

2021-04-22

Transethnic Genome-Wide Association Study Provides Insights in the Genetic Architecture and Heritability of Long QT Syndrome.

Lahrouchi N, Tadros R et al.

Circulation

Long QT syndrome

2020-05-20

Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection.

Turley TN, O'Byrne MM et al.

JAMA Cardiol

Spontaneous coronary artery dissection

2020-05-06

Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval.

Ramírez J, van Duijvenboden S et al.

Am J Hum Genet

TPE interval (resting)

2020-04-29

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.

Teumer A, Trenkwalder T et al.

JCI Insight

Early cardiac repolarization

2019-10-10

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Prins BP, Mead TJ et al.

Genome Biol

QRS duration

2018-07-17

Genome-Wide Associations of Global Electrical Heterogeneity ECG Phenotype: The ARIC (Atherosclerosis Risk in Communities) Study and CHS (Cardiovascular Health Study).

Tereshchenko LG, Sotoodehnia N et al.

J Am Heart Assoc

Global electrical heterogeneity phenotypes

2018-04-05

Identification of three novel genetic variations associated with electrocardiographic traits (QRS duration and PR interval) in East Asians.

Hong KW, Lim JE et al.

Hum Mol Genet

PR interval

2014-07-17

Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization.

Arking DE, Pulit SL et al.

Nat Genet

QT interval

2014-06-22