Active: Atherosclerosis Clear all

GWAS 2023-11-10

Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.

Kheirkhah A, Schachtl-Riess JF et al.

Atherosclerosis

Background and aims: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of lip...

PCSK9 levels

20579

Participants

N/A

Studies

Details PubMed

GWAS 2021-12-06

Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia.

Trinder M, Vikulova D et al.

Atherosclerosis

Background and aims: Familial combined hyperlipidemia (FCHL) is one of the most common inherited lip...

Familial combined hyperlipidemia defined by Brunzell criteria

349222

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-15

Genome-wide association study revealed novel candidate gene loci associated with soluble E-selectin levels in a Taiwanese population.

Teng MS, Hsu LA et al.

Atherosclerosis

Background and aims: Increase soluble E-selectin (sE-selectin) levels are associated with various in...

Soluble E-selectin levels

4525

Participants

N/A

Studies

Details PubMed

GWAS 2021-01-19

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study.

Hsu LA, Chou HH et al.

Atherosclerosis

Background and aims: Platelet count (PLT) is a predictor of metabolic and inflammation-related disor...

Platelet count

17037

Participants

N/A

Studies

Details PubMed

GWAS 2020-02-14

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

Backgrounds and aims: Several genes are known to contribute to the levels and metabolism of HDL-C, h...

HDL cholesterol levels

7738

Participants

N/A

Studies

Details PubMed

GWAS 2018-12-28

LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study.

Silbernagel G, Scharnagl H et al.

Atherosclerosis

Background and aims: High concentrations of low density lipoprotein (LDL) triglycerides have been as...

Low density lipoprotein triglyceride levels

2900

Participants

N/A

Studies

Details PubMed

GWAS 2018-04-12

Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery.

Cheon EJ, Cha DH et al.

Atherosclerosis

Background and aims: Although the importance of the functional properties of high-density lipoprotei...

Cholesterol efflux capacity

Replicated

765

Participants

N/A

Studies

Details PubMed

GWAS 2017-02-24

Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.

Pott J, Burkhardt R et al.

Atherosclerosis

Background and aims: Carotid artery plaque is an established marker of subclinical atherosclerosis a...

Carotid plaque burden

7189

Participants

N/A

Studies

Details PubMed

GWAS 2016-02-01

A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.

Wakil SM, Ram R et al.

Atherosclerosis

Multiple loci have been identified for coronary artery disease (CAD) by genome-wide association stud...

Coronary artery disease

Replicated

6941

Participants

N/A

Studies

Details PubMed

GWAS 2015-09-05

Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.

Xie G, Myint PK et al.

Atherosclerosis

Carotid artery intima media thickness (IMT) in human is a marker of subclinical atherosclerosis with...

Carotid intima media thickness

810

Participants

N/A

Studies

Details PubMed

GWAS 2015-04-16

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.

Dong C, Della-Morte D et al.

Atherosclerosis

There is an established sex-difference in carotid artery intima-media thickness (cIMT), a recognized...

Carotid artery intima media thickness (sex interaction)

Replicated

1341

Participants

N/A

Studies

Details PubMed

GWAS 2014-04-26

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

Postmus I, Johnson PC et al.

Atherosclerosis

Statin therapy is widely used in the prevention and treatment of cardiovascular events and is associ...

Cardiovascular event reduction in the elderly at risk for vascular disease (statin therapy interaction)

Replicated

6477

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Meta-GWAS on PCSK9 concentrations reveals associations of novel loci outside the PCSK9 locus in White populations.

Kheirkhah A, Schachtl-Riess JF et al.

Atherosclerosis

PCSK9 levels

2023-11-10

Polygenic architecture and cardiovascular risk of familial combined hyperlipidemia.

Trinder M, Vikulova D et al.

Atherosclerosis

Familial combined hyperlipidemia defined by Brunzell criteria

2021-12-06

Genome-wide association study revealed novel candidate gene loci associated with soluble E-selectin levels in a Taiwanese population.

Teng MS, Hsu LA et al.

Atherosclerosis

Soluble E-selectin levels

2021-10-15

Circulating chemerin levels are determined through circulating platelet counts in nondiabetic Taiwanese people: A bidirectional Mendelian randomization study.

Hsu LA, Chou HH et al.

Atherosclerosis

Platelet count

2021-01-19

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.

Feitosa MF, Lunetta KL et al.

Atherosclerosis

HDL cholesterol levels

2020-02-14

LDL triglycerides, hepatic lipase activity, and coronary artery disease: An epidemiologic and Mendelian randomization study.

Silbernagel G, Scharnagl H et al.

Atherosclerosis

Low density lipoprotein triglyceride levels

2018-12-28

Novel association between CDKAL1 and cholesterol efflux capacity: Replication after GWAS-based discovery.

Cheon EJ, Cha DH et al.

Atherosclerosis

Cholesterol efflux capacity

2018-04-12

Genome-wide meta-analysis identifies novel loci of plaque burden in carotid artery.

Pott J, Burkhardt R et al.

Atherosclerosis

Carotid plaque burden

2017-02-24

A genome-wide association study reveals susceptibility loci for myocardial infarction/coronary artery disease in Saudi Arabs.

Wakil SM, Ram R et al.

Atherosclerosis

Coronary artery disease

2016-02-01

Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.

Xie G, Myint PK et al.

Atherosclerosis

Carotid intima media thickness

2015-09-05

Genetic variants in LEKR1 and GALNT10 modulate sex-difference in carotid intima-media thickness: a genome-wide interaction study.

Dong C, Della-Morte D et al.

Atherosclerosis

Carotid artery intima media thickness (sex interaction)

2015-04-16

In search for genetic determinants of clinically meaningful differential cardiovascular event reduction by pravastatin in the PHArmacogenetic study of Statins in the Elderly at risk (PHASE)/PROSPER study.

Postmus I, Johnson PC et al.

Atherosclerosis

Cardiovascular event reduction in the elderly at risk for vascular disease (statin therapy interaction)

2014-04-26