Active: Clin Pharmacol Ther Clear all

GWAS 2024-03-19

A Genome-Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early-Stage Breast Cancer Patients.

Sanchez-Spitman AB, Böhringer S et al.

Clin Pharmacol Ther

Tamoxifen is part of the standard of care of endocrine therapy for adjuvant treatment of breast canc...

Endoxifen concentration in tamoxifen-treated breast cancer

608

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-17

Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.

Mykkänen AJH, Tarkiainen EK et al.

Clin Pharmacol Ther

In a genome-wide association study of atorvastatin pharmacokinetics in 158 healthy volunteers, the S...

AUC of atorvastatin

158

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-29

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.

Asiimwe IG, Walker L et al.

Clin Pharmacol Ther

Thiazide diuretics, widely used in hypertension, cause a variety of adverse reactions, including hyp...

Blood Glucose variance level in bendroflumethiazide treated hypertension

95493

Participants

N/A

Studies

Details PubMed

GWAS 2024-02-19

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline.

Chenoweth MJ, Kim YJ et al.

Clin Pharmacol Ther

Varenicline, the most efficacious smoking cessation monotherapy, produces abnormal dreams. Although ...

Abnormal dreams on treatment with varenicline in smokers

Replicated

325

Participants

N/A

Studies

Details PubMed

GWAS 2023-05-07

Genome-wide association studies categorized by class of anti-hypertensive drugs reveal complex pathogenesis of hypertension with drug resistance.

Yamazaki K, Terao C et al.

Clin Pharmacol Ther

Resistant hypertension is defined as uncontrolled blood pressure (BP) despite the use of three or mo...

Resistance to antihypertensive treatment in hypertension

31989

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-27

Genome-wide association study of methotrexate-induced liver injury in rheumatoid arthritis patients.

Eektimmerman F, Swen JJ et al.

Clin Pharmacol Ther

Hepatotoxicity is a serious adverse drug reaction related to methotrexate (MTX). However, the cause ...

Methotrexate-induced liver injury in rheumatoid arthritis

419

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-11

Cross-ancestry GWAS defines the extended CYP2D6 locus as the principal genetic determinant of endoxifen plasma concentrations.

Khor CC, Winter S et al.

Clin Pharmacol Ther

The therapeutic efficacy of tamoxifen is predominantly mediated by its active metabolites 4-hydroxy-...

Endoxifen levels in tamoxifen-treated hormone-receptor-positive breast cancer

497

Participants

N/A

Studies

Details PubMed

GWAS 2022-06-02

Genome-wide association study of simvastatin pharmacokinetics.

Mykkänen AJH, Taskinen S et al.

Clin Pharmacol Ther

We investigated genetic determinants of single-dose simvastatin pharmacokinetics in a prospective st...

AUC of simvastatin lactone

170

Participants

N/A

Studies

Details PubMed

GWAS 2021-08-14

Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-related Osteonecrosis of the Jaw.

Yang G, Singh S et al.

Clin Pharmacol Ther

Medication-related osteonecrosis of the jaw (MRONJ) is a rare but serious drug-related adverse event...

Bisphosphonate-related osteonecrosis of the jaw in cancer (i.v. bisphosphonate)

Replicated

3639

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-07

Adverse Cardiovascular Outcomes and Antihypertensive treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies (ICAPS).

McDonough CW, Warren HR et al.

Clin Pharmacol Ther

We sought to identify genome-wide variants influencing antihypertensive drug response and adverse ca...

Adverse cardiovascular outcome x beta blockers interaction in hypertension

9195

Participants

N/A

Studies

Details PubMed

GWAS 2021-03-26

Class II HLA Variants Associate with Risk of Pegaspargase Hypersensitivity.

Liu Y, Yang W et al.

Clin Pharmacol Ther

We conducted the first human leukocyte antigen (HLA) allele and genome-wide association study to ide...

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2168

Participants

N/A

Studies

Details PubMed

GWAS 2020-11-01

Genetic risk factors in drug-induced liver injury due to isoniazid-containing anti-tuberculosis drug regimens.

Nicoletti P, Devarbhavi H et al.

Clin Pharmacol Ther

Drug-induced liver injury (DILI) is a complication of treatment with antituberculosis (TB) drugs, es...

Drug-induced liver injury (isoniazid-containing anti-tuberculosis drugs)

10467

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

A Genome-Wide Association Study of Endoxifen Serum Concentrations and Adjuvant Tamoxifen Efficacy in Early-Stage Breast Cancer Patients.

Sanchez-Spitman AB, Böhringer S et al.

Clin Pharmacol Ther

Endoxifen concentration in tamoxifen-treated breast cancer

2024-03-19

Genome-Wide Association Study of Atorvastatin Pharmacokinetics: Associations With SLCO1B1, UGT1A3, and LPP.

Mykkänen AJH, Tarkiainen EK et al.

Clin Pharmacol Ther

AUC of atorvastatin

2024-03-17

Genetic Determinants of Thiazide-Induced Hyperuricemia, Hyperglycemia, and Urinary Electrolyte Disturbances - A Genome-Wide Evaluation of the UK Biobank.

Asiimwe IG, Walker L et al.

Clin Pharmacol Ther

Blood Glucose variance level in bendroflumethiazide treated hypertension

2024-02-29

Genetic Prediction of Smoking Cessation Medication Side Effects: A Genome-Wide Investigation of Abnormal Dreams on Varenicline.

Chenoweth MJ, Kim YJ et al.

Clin Pharmacol Ther

Abnormal dreams on treatment with varenicline in smokers

2024-02-19

Genome-wide association studies categorized by class of anti-hypertensive drugs reveal complex pathogenesis of hypertension with drug resistance.

Yamazaki K, Terao C et al.

Clin Pharmacol Ther

Resistance to antihypertensive treatment in hypertension

2023-05-07

Genome-wide association study of methotrexate-induced liver injury in rheumatoid arthritis patients.

Eektimmerman F, Swen JJ et al.

Clin Pharmacol Ther

Methotrexate-induced liver injury in rheumatoid arthritis

2023-01-27

Cross-ancestry GWAS defines the extended CYP2D6 locus as the principal genetic determinant of endoxifen plasma concentrations.

Khor CC, Winter S et al.

Clin Pharmacol Ther

Endoxifen levels in tamoxifen-treated hormone-receptor-positive breast cancer

2023-01-11

Genome-wide association study of simvastatin pharmacokinetics.

Mykkänen AJH, Taskinen S et al.

Clin Pharmacol Ther

AUC of simvastatin lactone

2022-06-02

Genome-wide Association Study Identified Chromosome 8 Locus Associated with Medication-related Osteonecrosis of the Jaw.

Yang G, Singh S et al.

Clin Pharmacol Ther

Bisphosphonate-related osteonecrosis of the jaw in cancer (i.v. bisphosphonate)

2021-08-14

Adverse Cardiovascular Outcomes and Antihypertensive treatment: A Genome-Wide Interaction Meta-Analysis in the International Consortium for Antihypertensive Pharmacogenomics Studies (ICAPS).

McDonough CW, Warren HR et al.

Clin Pharmacol Ther

Adverse cardiovascular outcome x beta blockers interaction in hypertension

2021-07-07

Class II HLA Variants Associate with Risk of Pegaspargase Hypersensitivity.

Liu Y, Yang W et al.

Clin Pharmacol Ther

Asparaginase hypersensitivity in acute lymphoblastic leukemia

2021-03-26

Genetic risk factors in drug-induced liver injury due to isoniazid-containing anti-tuberculosis drug regimens.

Nicoletti P, Devarbhavi H et al.

Clin Pharmacol Ther

Drug-induced liver injury (isoniazid-containing anti-tuberculosis drugs)

2020-11-01