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GWAS 2025-06-21

Genome-wide association studies and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating polyunsaturated, monounsaturated, and saturated fatty acids.

Sun Y, Xu H et al.

HGG Adv

Previous genome-wide association studies (GWAS) have identified genetic loci associated with the cir...

Polyunsaturated fatty acid levels

511

Participants

N/A

Studies

Details PubMed

GWAS 2025-06-09

Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity.

Mies G, Tsao NL et al.

HGG Adv

Uveal melanoma (UM) is a rare but frequently metastasizing cancer. Genome-wide association studies h...

Uveal melanoma

354387

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-21

A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci.

Ihejirika SA, Chiang AH et al.

HGG Adv

Fish oil supplements (FOS) are known to alter circulating levels of polyunsaturated fatty acids (PUF...

Plasma docosahexaenoic acid percentage of total fatty acids x fish oil supplement use interaction (1df)

200060

Participants

N/A

Studies

Details PubMed

GWAS 2025-01-29

Trans-ancestry genome wide association study of childhood body mass index identifies novel loci and age-specific effects.

Downie CG, Shrestha P et al.

HGG Adv

Over the past 30 years, obesity prevalence has markedly increased globally, including among children...

Body mass index z-score

84840

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-10

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

While brainstem regions are central regulators of blood pressure, the neuronal mechanisms underlying...

Systolic blood pressure

174014

Participants

N/A

Studies

Details PubMed

GWAS 2024-12-06

Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Downie CG, Highland HM et al.

HGG Adv

Bioactive fatty acid-derived oxylipin molecules play key roles mediating inflammation and oxidative ...

D-series Resolvin/Maresin/Protectin levels (359.2214_0.37) x waist circumference interaction (2df)

11478

Participants

N/A

Studies

Details PubMed

GWAS 2024-10-22

Variants in the β-globin Locus are Associated with Pneumonia in African American Children.

Halligan NLN, Hanks SC et al.

HGG Adv

In African American adults, the strongest genetic predictor of pneumonia appears to be the A allele ...

Pneumonia

1000

Participants

N/A

Studies

Details PubMed

GWAS 2024-09-07

Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population.

Gautam Y, Satish L et al.

HGG Adv

Atopic dermatitis (AD) is a chronic itchy inflammatory disease of the skin. Genetic studies have ide...

Atopic dermatitis

1725

Participants

N/A

Studies

Details PubMed

GWAS 2024-08-22

The performance of AlphaMissense to identify genes influencing disease.

Chen Y, Butler-Laporte G et al.

HGG Adv

A novel algorithm, AlphaMissense, has been shown to have an improved ability to predict the pathogen...

Acute renal failure (AlphaMissense) (Gene-based burden)

443182

Participants

N/A

Studies

Details PubMed

GWAS 2024-08-20

Mid-pass Whole-genome Sequencing in a Malagasy Cohort Uncovers Body Composition Associations.

Hamid I, Raveloson SNS et al.

HGG Adv

The majority of human genomic research studies have been conducted in European-ancestry cohorts, red...

Basal metabolic rate

214

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-18

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Previous genome-wide association studies (GWASs) for adiponectin, a complex trait linked to type 2 d...

Adiponectin levels

Replicated

81993

Participants

N/A

Studies

Details PubMed

GWAS 2023-09-13

Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in Latinos.

Jeon S, Lo YC et al.

HGG Adv

The utility of polygenic risk score (PRS) models has not been comprehensively evaluated for childhoo...

Acute lymphoblastic leukemia (childhood)

77632

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association studies and multi-omics integrative analysis reveal novel loci and their molecular mechanisms for circulating polyunsaturated, monounsaturated, and saturated fatty acids.

Sun Y, Xu H et al.

HGG Adv

Polyunsaturated fatty acid levels

2025-06-21

Meta-analysis of uveal melanoma genome-wide association studies identifies novel risk loci and population effect size heterogeneity.

Mies G, Tsao NL et al.

HGG Adv

Uveal melanoma

2025-06-09

A multi-level gene-diet interaction analysis of fish oil and 14 polyunsaturated fatty acid traits identifies the FADS and GPR12 loci.

Ihejirika SA, Chiang AH et al.

HGG Adv

Plasma docosahexaenoic acid percentage of total fatty acids x fish oil supplement use interaction (1df)

2025-05-21

Trans-ancestry genome wide association study of childhood body mass index identifies novel loci and age-specific effects.

Downie CG, Shrestha P et al.

HGG Adv

Body mass index z-score

2025-01-29

Large-scale brainstem neuroimaging and genetic analyses provide new insights into the neuronal mechanisms of hypertension.

Gurholt TP, Elvsåshagen T et al.

HGG Adv

Systolic blood pressure

2024-12-10

Genome-wide association study reveals shared and distinct genetic architecture underlying fatty acid and bioactive oxylipin metabolites in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Downie CG, Highland HM et al.

HGG Adv

D-series Resolvin/Maresin/Protectin levels (359.2214_0.37) x waist circumference interaction (2df)

2024-12-06

Variants in the β-globin Locus are Associated with Pneumonia in African American Children.

Halligan NLN, Hanks SC et al.

HGG Adv

Pneumonia

2024-10-22

Joint genotype and ancestry analysis identify novel loci associated with atopic dermatitis in African American population.

Gautam Y, Satish L et al.

HGG Adv

Atopic dermatitis

2024-09-07

The performance of AlphaMissense to identify genes influencing disease.

Chen Y, Butler-Laporte G et al.

HGG Adv

Acute renal failure (AlphaMissense) (Gene-based burden)

2024-08-22

Mid-pass Whole-genome Sequencing in a Malagasy Cohort Uncovers Body Composition Associations.

Hamid I, Raveloson SNS et al.

HGG Adv

Basal metabolic rate

2024-08-20

A Cross-ancestry genome-wide meta-analysis, fine-mapping, and gene prioritization approach to characterize the genetic architecture of adiponectin.

Sarsani V, Brotman SM et al.

HGG Adv

Adiponectin levels

2023-10-18

Evaluating Genomic Polygenic Risk Scores for Childhood Acute Lymphoblastic Leukemia in Latinos.

Jeon S, Lo YC et al.

HGG Adv

Acute lymphoblastic leukemia (childhood)

2023-09-13