Active: Hypertension Clear all

GWAS 2022-06-02

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.

Kelly TN, Sun X et al.

Hypertension

The availability of whole-genome sequencing data in large studies has enabled the assessment of codi...

Diastolic blood pressure

Replicated

764135

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-28

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.

Gill D, Cameron AC et al.

Hypertension

Serum urate has been implicated in hypertension and cardiovascular disease, but it is not known whet...

Urate levels

454183

Participants

N/A

Studies

Details PubMed

GWAS 2017-07-24

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Wain LV, Vaez A et al.

Hypertension

Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial gene...

Diastolic blood pressure

Replicated

378379

Participants

N/A

Studies

Details PubMed

GWAS 2016-10-31

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Salvi E, Wang Z et al.

Hypertension

This study aimed to identify novel loci influencing the antihypertensive response to hydrochlorothia...

Diastolic blood pressure response to hydrochlorothiazide in hypertension

Replicated

2169

Participants

N/A

Studies

Details PubMed

GWAS 2016-08-01

Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study.

Li C, He J et al.

Hypertension

We performed genome-wide analyses to identify genomic loci that interact with sodium to influence bl...

Diastolic blood pressure x sodium interaction (1df test)

Replicated

2651

Participants

N/A

Studies

Details PubMed

GWAS 2013-09-03

Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.

Kelly TN, Takeuchi F et al.

Hypertension

We conducted a genome-wide association study meta-analysis of mean arterial pressure and pulse press...

Blood pressure

Replicated

55383

Participants

N/A

Studies

Details PubMed

GWAS 2013-06-10

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.

Turner ST, Boerwinkle E et al.

Hypertension

To identify novel genes influencing blood pressure response to thiazide diuretic therapy for hyperte...

Response to diuretic therapy in hypertension

Replicated

1265

Participants

N/A

Studies

Details PubMed

GWAS 2013-02-04

Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.

Verweij N, Mahmud H et al.

Hypertension

Endothelin-1 (ET-1) and adrenomedullin (ADM) are circulating vasoactive peptides involved in vascula...

Circulating vasoactive peptide levels

Replicated

6674

Participants

N/A

Studies

Details PubMed

GWAS 2012-05-07

Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

Turner ST, Bailey KR et al.

Hypertension

To identify genes influencing blood pressure response to an angiotensin II receptor blocker, single ...

Response to angiotensin II receptor blocker therapy

391

Participants

N/A

Studies

Details PubMed

GWAS 2008-06-30

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.

Turner ST, Bailey KR et al.

Hypertension

We conducted a genome-wide association study to identify novel genes influencing diastolic blood pre...

Response to diuretic therapy

389

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Insights From a Large-Scale Whole-Genome Sequencing Study of Systolic Blood Pressure, Diastolic Blood Pressure, and Hypertension.

Kelly TN, Sun X et al.

Hypertension

Diastolic blood pressure

2022-06-02

Urate, Blood Pressure, and Cardiovascular Disease: Evidence From Mendelian Randomization and Meta-Analysis of Clinical Trials.

Gill D, Cameron AC et al.

Hypertension

Urate levels

2020-12-28

Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.

Wain LV, Vaez A et al.

Hypertension

Diastolic blood pressure

2017-07-24

Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.

Salvi E, Wang Z et al.

Hypertension

Diastolic blood pressure response to hydrochlorothiazide in hypertension

2016-10-31

Genome-Wide Gene-Sodium Interaction Analyses on Blood Pressure: The Genetic Epidemiology Network of Salt-Sensitivity Study.

Li C, He J et al.

Hypertension

Diastolic blood pressure x sodium interaction (1df test)

2016-08-01

Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.

Kelly TN, Takeuchi F et al.

Hypertension

Blood pressure

2013-09-03

Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.

Turner ST, Boerwinkle E et al.

Hypertension

Response to diuretic therapy in hypertension

2013-06-10

Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.

Verweij N, Mahmud H et al.

Hypertension

Circulating vasoactive peptide levels

2013-02-04

Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.

Turner ST, Bailey KR et al.

Hypertension

Response to angiotensin II receptor blocker therapy

2012-05-07

Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic.

Turner ST, Bailey KR et al.

Hypertension

Response to diuretic therapy

2008-06-30