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GWAS 2025-05-05

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Cole JB, Dahlström EH et al.

J Am Soc Nephrol

Abstract Key Points: Comprehensive genome-wide association study of eGFR in diabetes, accounting for...

eGFR in diabetes mellitus (loose) kidney disease cases (minimal adjustment)

5064

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-03

Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.

Lovegrove CE, Bešević J et al.

J Am Soc Nephrol

Significance statement: Kidney stone disease is a common disorder with poorly understood pathophysio...

Kidney stone disease

739048

Participants

N/A

Studies

Details PubMed

GWAS 2023-10-02

Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy.

Li M, Wang YN et al.

J Am Soc Nephrol

Significance statement: Genome-wide association studies have identified nearly 20 IgA nephropathy su...

IgA nephropathy

Replicated

32017

Participants

N/A

Studies

Details PubMed

GWAS 2023-06-01

Genome-Wide Association Study of Chronic Kidney Disease Progression.

Robinson-Cohen C, Triozzi JL et al.

J Am Soc Nephrol

Significance statement: Rapid progression of CKD is associated with poor clinical outcomes. Most pre...

Estimated glomerular filtration rate

116960

Participants

N/A

Studies

Details PubMed

GWAS 2023-02-02

Genome-wide Association Study in Acute Tubulointerstitial Nephritis.

Zhou XJ, Su T et al.

J Am Soc Nephrol

Significance statement: Polymorphisms of HLA genes may confer susceptibility to acute tubulointersti...

Acute tubulointerstitial nephritis

2890

Participants

N/A

Studies

Details PubMed

GWAS 2023-01-05

Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

Han M, Moon S et al.

J Am Soc Nephrol

Significance statement: eGFR slope has been used as a surrogate outcome for progression of CKD. Howe...

eGFR slope in chronic kidney disease

Replicated

4236

Participants

N/A

Studies

Details PubMed

GWAS 2022-03-01

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.

Joseph CB, Mariniello M et al.

J Am Soc Nephrol

Uromodulin, the most abundant protein excreted in normal urine, plays major roles in kidney physiolo...

Urinary uromodulin levels (raw)

29315

Participants

N/A

Studies

Details PubMed

GWAS 2021-10-20

Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identify European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States.

Horimoto ARVR, Xue D et al.

J Am Soc Nephrol

Admixture mapping is a powerful approach for gene mapping of complex traits that leverages the diver...

Estimated glomerular filtration rate

12601

Participants

N/A

Studies

Details PubMed

GWAS 2021-09-21

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.

Yu Z, Jin J et al.

J Am Soc Nephrol

Genome-wide association studies (GWAS) have revealed numerous loci for kidney function (eGFR). The r...

Estimated glomerular filtration rate (creatinine)

1159871

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-03

Medical Records-Based Genetic Studies of the Complement System.

Khan A, Shang N et al.

J Am Soc Nephrol

Genetic variants in complement genes have been associated with a wide range of human disease states,...

Complement C3 levels

3949

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-17

Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux.

Verbitsky M, Krithivasan P et al.

J Am Soc Nephrol

Vesicoureteral reflux (VUR) is a common, familial genitourinary disorder, and a major cause of pedia...

Vesicoureteral reflux

6761

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-16

Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.

Wang YN, Zhou XJ et al.

J Am Soc Nephrol

Galactose-deficient IgA1 plays a key role in the pathogenesis of IgA nephropathy, the most common pr...

Serum galactose-deficient IgA1 levels in IgA nephropathy

Replicated

1162

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Cole JB, Dahlström EH et al.

J Am Soc Nephrol

eGFR in diabetes mellitus (loose) kidney disease cases (minimal adjustment)

2025-05-05

Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.

Lovegrove CE, Bešević J et al.

J Am Soc Nephrol

Kidney stone disease

2023-10-03

Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy.

Li M, Wang YN et al.

J Am Soc Nephrol

IgA nephropathy

2023-10-02

Genome-Wide Association Study of Chronic Kidney Disease Progression.

Robinson-Cohen C, Triozzi JL et al.

J Am Soc Nephrol

Estimated glomerular filtration rate

2023-06-01

Genome-wide Association Study in Acute Tubulointerstitial Nephritis.

Zhou XJ, Su T et al.

J Am Soc Nephrol

Acute tubulointerstitial nephritis

2023-02-02

Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

Han M, Moon S et al.

J Am Soc Nephrol

eGFR slope in chronic kidney disease

2023-01-05

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.

Joseph CB, Mariniello M et al.

J Am Soc Nephrol

Urinary uromodulin levels (raw)

2022-03-01

Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identify European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States.

Horimoto ARVR, Xue D et al.

J Am Soc Nephrol

Estimated glomerular filtration rate

2021-10-20

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.

Yu Z, Jin J et al.

J Am Soc Nephrol

Estimated glomerular filtration rate (creatinine)

2021-09-21

Medical Records-Based Genetic Studies of the Complement System.

Khan A, Shang N et al.

J Am Soc Nephrol

Complement C3 levels

2021-05-03

Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux.

Verbitsky M, Krithivasan P et al.

J Am Soc Nephrol

Vesicoureteral reflux

2021-02-17

Interaction between G ALNT12 and C1GALT1 Associates with Galactose-Deficient IgA1 and IgA Nephropathy.

Wang YN, Zhou XJ et al.

J Am Soc Nephrol

Serum galactose-deficient IgA1 levels in IgA nephropathy

2021-02-16

Health & Traits Publications

Genome-Wide Association Study of Quantitative Kidney Function in 52,531 Individuals with Diabetes Identifies Five Diabetes-Specific Loci.

Central Adiposity Increases Risk of Kidney Stone Disease via Effects on Serum Calcium Concentrations.

Genome-Wide Association Analysis of Protein-Coding Variants in IgA Nephropathy.

Genome-Wide Association Study of Chronic Kidney Disease Progression.

Genome-wide Association Study in Acute Tubulointerstitial Nephritis.

Novel Genetic Variants Associated with Chronic Kidney Disease Progression.

Meta-GWAS Reveals Novel Genetic Variants Associated with Urinary Excretion of Uromodulin.

Genome-Wide Admixture Mapping of Estimated Glomerular Filtration Rate and Chronic Kidney Disease Identify European and African Ancestry-of-Origin Loci in Hispanic and Latino Individuals in the United States.

Polygenic Risk Scores for Kidney Function and Their Associations with Circulating Proteome, and Incident Kidney Diseases.

Medical Records-Based Genetic Studies of the Complement System.

Copy Number Variant Analysis and Genome-wide Association Study Identify Loci with Large Effect for Vesicoureteral Reflux.

Interaction between <i>G</i> <i>ALNT12</i> and <i>C1GALT1</i> Associates with Galactose-Deficient IgA1 and IgA Nephropathy.