Active: J Bone Miner Res Clear all

GWAS 2024-01-12

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width (FNW) derived from DXA scans may provide a useful adjunct to hip fracture predict...

Femoral neck width

38150

Participants

N/A

Studies

Details PubMed

GWAS 2023-08-24

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Although the impact of sex hormones on bone metabolism is well-documented, effect of their primary m...

Sex hormone-binding globulin levels and heel estimated bone mineral density

832949

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-22

Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use.

Otomo N, Lu HF et al.

J Bone Miner Res

Adolescent idiopathic scoliosis (AIS) is a common disease causing three-dimensional spinal deformity...

Adolescent idiopathic scoliosis (Cobb angle)

4465

Participants

N/A

Studies

Details PubMed

GWAS 2021-05-06

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

Zeng H, Ge J et al.

J Bone Miner Res

Recent advances indicate that bone and energy metabolism are closely related. However, little direct...

Serum 25-Hydroxyvitamin D levels

Replicated

4665

Participants

N/A

Studies

Details PubMed

GWAS 2020-12-18

Genome-wide Association Studies Reveal Novel Locus With Sex-/Therapy-Specific Fracture Risk Effects in Childhood Cancer Survivors.

Im C, Li N et al.

J Bone Miner Res

Childhood cancer survivors treated with radiation therapy (RT) and osteotoxic chemotherapies are at ...

First fracture in long-term childhood cancer survivors (time to event)

Replicated

1935

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-02

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.

Zheng J, Maerz W et al.

J Bone Miner Res

In bone, sclerostin is mainly osteocyte-derived and plays an important local role in adaptive respon...

Serum sclerostin levels

10584

Participants

N/A

Studies

Details PubMed

GWAS 2019-03-19

Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry.

Hsu YH, Estrada K et al.

J Bone Miner Res

Hip geometry is an important predictor of fracture. We performed a meta-analysis of GWAS studies in ...

Femoral neck length

Replicated

27053

Participants

N/A

Studies

Details PubMed

GWAS 2019-02-28

Joint Association Analysis Identified 18 New Loci for Bone Mineral Density.

Pei YF, Liu L et al.

J Bone Miner Res

Bone mineral density (BMD) at various skeletal sites have shared genetic determinants. In the presen...

Total body bone mineral density (MTAG)

66628

Participants

N/A

Studies

Details PubMed

GWAS 2019-02-19

A meta-analysis of genome-wide association studies identifies three loci associated with stiffness index of the calcaneus.

Lu HF, Hung KS et al.

J Bone Miner Res

The stiffness index (SI) from quantitative ultrasound measurements is a good indicator of BMD and ma...

Calcaneus stiffness index

Replicated

10697

Participants

N/A

Studies

Details PubMed

GWAS 2018-10-15

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies.

Baird DA, Evans DS et al.

J Bone Miner Res

We aimed to report the first genomewide association study (GWAS) meta-analysis of dual-energy X-ray ...

Hip shape (DXA scan)

15934

Participants

N/A

Studies

Details PubMed

GWAS 2017-12-14

Multi-dimensional bone density phenotyping reveals new insights in to genetic regulation of the pediatric skeleton.

Mitchell JA, Chesi A et al.

J Bone Miner Res

Osteoporosis is a complex disease with developmental origins. It is therefore important to understan...

Pediatric areal bone mineral density (concordant skeletal phenotype)

Replicated

1885

Participants

N/A

Studies

Details PubMed

GWAS 2017-02-09

A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.

Chesi A, Mitchell JA et al.

J Bone Miner Res

Failure to achieve optimal bone mineral accretion during childhood and adolescence results in subseq...

Pediatric areal bone mineral density (radius)

Replicated

1419

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Femoral Neck Width Genetic Risk Score is A Novel Independent Risk Factor for Hip Fractures.

Tobias JH, Nethander M et al.

J Bone Miner Res

Femoral neck width

2024-01-12

Genetic correlation, shared loci and causal association between sex hormone-binding globulin and bone mineral density: insights from a large-scale genome-wide cross-trait analysis.

Qu Y, Xiao C et al.

J Bone Miner Res

Sex hormone-binding globulin levels and heel estimated bone mineral density

2023-08-24

Polygenic Risk Score of Adolescent Idiopathic Scoliosis for Potential Clinical Use.

Otomo N, Lu HF et al.

J Bone Miner Res

Adolescent idiopathic scoliosis (Cobb angle)

2021-06-22

Type 2 diabetes is causally associated with reduced serum osteocalcin: A genome-wide association and Mendelian randomization study.

Zeng H, Ge J et al.

J Bone Miner Res

Serum 25-Hydroxyvitamin D levels

2021-05-06

Genome-wide Association Studies Reveal Novel Locus With Sex-/Therapy-Specific Fracture Risk Effects in Childhood Cancer Survivors.

Im C, Li N et al.

J Bone Miner Res

First fracture in long-term childhood cancer survivors (time to event)

2020-12-18

Mendelian Randomization Analysis Reveals a Causal Influence of Circulating Sclerostin Levels on Bone Mineral Density and Fractures.

Zheng J, Maerz W et al.

J Bone Miner Res

Serum sclerostin levels

2019-08-02

Meta-Analysis of Genomewide Association Studies Reveals Genetic Variants for Hip Bone Geometry.

Hsu YH, Estrada K et al.

J Bone Miner Res

Femoral neck length

2019-03-19

Joint Association Analysis Identified 18 New Loci for Bone Mineral Density.

Pei YF, Liu L et al.

J Bone Miner Res

Total body bone mineral density (MTAG)

2019-02-28

A meta-analysis of genome-wide association studies identifies three loci associated with stiffness index of the calcaneus.

Lu HF, Hung KS et al.

J Bone Miner Res

Calcaneus stiffness index

2019-02-19

Identification of novel loci associated with hip shape: a meta-analysis of genome-wide association studies.

Baird DA, Evans DS et al.

J Bone Miner Res

Hip shape (DXA scan)

2018-10-15

Multi-dimensional bone density phenotyping reveals new insights in to genetic regulation of the pediatric skeleton.

Mitchell JA, Chesi A et al.

J Bone Miner Res

Pediatric areal bone mineral density (concordant skeletal phenotype)

2017-12-14

A Genomewide Association Study Identifies Two Sex-Specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites.

Chesi A, Mitchell JA et al.

J Bone Miner Res

Pediatric areal bone mineral density (radius)

2017-02-09