Active: JCI Insight Clear all

GWAS 2022-04-21

Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.

Li Y, Cheng Y et al.

JCI Insight

Uromodulin (UMOD) is a major risk gene for monogenic and complex forms of kidney disease. The encode...

Serum uromodulin levels (antibody-based assay)

13985

Participants

N/A

Studies

Details PubMed

GWAS 2022-02-08

Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease.

Yu M, Tcheandjieu C et al.

JCI Insight

The fibrous annulus of the mitral valve plays an important role in valvular function and cardiac phy...

Mitral valve annular diameter (left ventricle systole)

27156

Participants

N/A

Studies

Details PubMed

GWAS 2020-07-23

Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action.

Cairns J, Ingle JN et al.

JCI Insight

Aromatase inhibitors (AIs) reduce breast cancer recurrence and prolong survival, but up to 30% of pa...

Estrogen level change in anastrozole-treated breast cancer

624

Participants

N/A

Studies

Details PubMed

GWAS 2019-10-10

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.

Teumer A, Trenkwalder T et al.

JCI Insight

BACKGROUNDThe presence of an early repolarization pattern (ERP) on the surface ECG is associated wit...

Early cardiac repolarization

39456

Participants

N/A

Studies

Details PubMed

GWAS 2018-03-22

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.

Li XS, Wang Z et al.

JCI Insight

Using an untargeted metabolomics approach in initial (N = 99 subjects) and replication cohorts (N = ...

Plasma trimethyllysine levels

1297

Participants

N/A

Studies

Details PubMed

GWAS 2017-11-02

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A et al.

JCI Insight

The secretion of insulin and glucagon from the pancreas and the incretin hormones glucagon-like pept...

Insulin levels in response to oral glucose tolerance test (fasting)

Replicated

8249

Participants

N/A

Studies

Details PubMed

GWAS 2017-03-23

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.

Liu TC, Naito T et al.

JCI Insight

BACKGROUND. Morphological patterns of Paneth cells are a prognostic biomarker in Western Crohn's dis...

Paneth cell defects in Crohn's disease

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases.

Li Y, Cheng Y et al.

JCI Insight

Serum uromodulin levels (antibody-based assay)

2022-04-21

Computational estimates of annular diameter reveal genetic determinants of mitral valve function and disease.

Yu M, Tcheandjieu C et al.

JCI Insight

Mitral valve annular diameter (left ventricle systole)

2022-02-08

Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action.

Cairns J, Ingle JN et al.

JCI Insight

Estrogen level change in anastrozole-treated breast cancer

2020-07-23

KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.

Teumer A, Trenkwalder T et al.

JCI Insight

Early cardiac repolarization

2019-10-10

Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.

Li XS, Wang Z et al.

JCI Insight

Plasma trimethyllysine levels

2018-03-22

Genetic determinants of circulating GIP and GLP-1 concentrations.

Almgren P, Lindqvist A et al.

JCI Insight

Insulin levels in response to oral glucose tolerance test (fasting)

2017-11-02

LRRK2 but not ATG16L1 is associated with Paneth cell defect in Japanese Crohn's disease patients.

Liu TC, Naito T et al.

JCI Insight

Paneth cell defects in Crohn's disease

2017-03-23