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GWAS 2025-11-20

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.

Barnes DR, Tyrer JP et al.

NPJ Genom Med

Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta...

High-grade serous ovarian cancer

120248

Participants

N/A

Studies

Details PubMed

GWAS 2025-09-29

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

Jordà P, Lai Y et al.

NPJ Genom Med

Common genetic variation detected by genome-wide association studies (GWAS) partially explains varia...

Atrial fibrillation (MTAG)

296021

Participants

N/A

Studies

Details PubMed

GWAS 2025-05-23

Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children.

Wang Y, Zhang Y et al.

NPJ Genom Med

To identify novel genetic loci for children refractive error, we performed a meta-analysis of two ge...

Spherical equivalent

Replicated

5330

Participants

N/A

Studies

Details PubMed

GWAS 2024-03-05

Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.

Ramachandran D, Tyrer JP et al.

NPJ Genom Med

Survival from ovarian cancer depends on the resection status after primary surgery. We performed gen...

Macroscopic residual disease after surgery in ovarian cancer (FIGO stage adjusted)

7111

Participants

N/A

Studies

Details PubMed

GWAS 2022-01-19

A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.

Chou WC, Chen WT et al.

NPJ Genom Med

Large-scale genome-wide associations comprising multiple studies have identified hundreds of genetic...

Hyperlipidemia

Replicated

12376

Participants

N/A

Studies

Details PubMed

GWAS 2021-07-27

Association between genes regulating neural pathways for quantitative traits of speech and language disorders.

Benchek P, Igo RP et al.

NPJ Genom Med

Speech sound disorders (SSD) manifest as difficulties in phonological memory and awareness, oral mot...

Multisyllabic word repetition

432

Participants

N/A

Studies

Details PubMed

GWAS 2021-06-11

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.

Chen G, Adeyemo A et al.

NPJ Genom Med

Serum bilirubin is associated with several clinical outcomes, including hypertension, type 2 diabete...

Total bilirubin levels

1127

Participants

N/A

Studies

Details PubMed

GWAS 2021-02-11

Mapping of susceptible variants for cold medicine-related Stevens-Johnson syndrome by whole-genome resequencing.

Kawai Y, Hitomi Y et al.

NPJ Genom Med

Stevens-Johnson syndrome (SJS) and its severe condition with extensive skin detachment and a poor pr...

Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications

551

Participants

N/A

Studies

Details PubMed

GWAS 2020-01-16

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

In pharmacogenomic studies of quantitative change, any association between genetic variants and the ...

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

1205

Participants

N/A

Studies

Details PubMed

GWAS 2019-08-29

Genome-wide association study for proliferative diabetic retinopathy in Africans.

Liu C, Chen G et al.

NPJ Genom Med

Proliferative diabetic retinopathy (PDR) is a sight-threatening complication of diabetes that is ass...

Proliferative diabetic retinopathy

Replicated

360

Participants

N/A

Studies

Details PubMed

GWAS 2019-01-21

Both rare and common genetic variants contribute to autism in the Faroe Islands.

Leblond CS, Cliquet F et al.

NPJ Genom Med

The number of genes associated with autism is increasing, but few studies have been performed on epi...

Autism

212

Participants

N/A

Studies

Details PubMed

GWAS 2017-03-10

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.

Mobuchon L, Battistella A et al.

NPJ Genom Med

Uveal melanoma, a rare malignant tumor of the eye, is predominantly observed in populations of Europ...

Uveal melanoma

Replicated

1120

Participants

N/A

Studies

Details PubMed

Title

Author

Journal

Disease/Trait

Date

Actions

Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer.

Barnes DR, Tyrer JP et al.

NPJ Genom Med

High-grade serous ovarian cancer

2025-11-20

Genetic analyses across cardiovascular traits: leveraging genetic correlations to empower locus discovery and prediction in common cardiovascular diseases.

Jordà P, Lai Y et al.

NPJ Genom Med

Atrial fibrillation (MTAG)

2025-09-29

Genome-wide association study identified novel loci and gene-environment interaction for refractive error in children.

Wang Y, Zhang Y et al.

NPJ Genom Med

Spherical equivalent

2025-05-23

Genome-wide association analyses of ovarian cancer patients undergoing primary debulking surgery identify candidate genes for residual disease.

Ramachandran D, Tyrer JP et al.

NPJ Genom Med

Macroscopic residual disease after surgery in ovarian cancer (FIGO stage adjusted)

2024-03-05

A common variant in 11q23.3 associated with hyperlipidemia is mediated by the binding and regulation of GATA4.

Chou WC, Chen WT et al.

NPJ Genom Med

Hyperlipidemia

2022-01-19

Association between genes regulating neural pathways for quantitative traits of speech and language disorders.

Benchek P, Igo RP et al.

NPJ Genom Med

Multisyllabic word repetition

2021-07-27

A UGT1A1 variant is associated with serum total bilirubin levels, which are causal for hypertension in African-ancestry individuals.

Chen G, Adeyemo A et al.

NPJ Genom Med

Total bilirubin levels

2021-06-11

Mapping of susceptible variants for cold medicine-related Stevens-Johnson syndrome by whole-genome resequencing.

Kawai Y, Hitomi Y et al.

NPJ Genom Med

Cold medicine-related Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) with severe ocular complications

2021-02-11

The impact of adjusting for baseline in pharmacogenomic genome-wide association studies of quantitative change.

Oni-Orisan A, Haldar T et al.

NPJ Genom Med

Response to statins (LDL cholesterol percent change)(baseline-unadjusted)

2020-01-16

Genome-wide association study for proliferative diabetic retinopathy in Africans.

Liu C, Chen G et al.

NPJ Genom Med

Proliferative diabetic retinopathy

2019-08-29

Both rare and common genetic variants contribute to autism in the Faroe Islands.

Leblond CS, Cliquet F et al.

NPJ Genom Med

Autism

2019-01-21

A GWAS in uveal melanoma identifies risk polymorphisms in the CLPTM1L locus.

Mobuchon L, Battistella A et al.

NPJ Genom Med

Uveal melanoma

2017-03-10