A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.
Potkin SG, Turner JA, Guffanti G et al.
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Abstract
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Genome-wide association studies (GWASs) are increasingly used to identify risk genes for complex illnesses including schizophrenia. These studies may require thousands of subjects to obtain sufficient power. We present an alternative strategy with increased statistical power over a case-control study that uses brain imaging as a quantitative trait (QT) in the context of a GWAS in schizophrenia.
46 European ancestry cases, 60 European ancestry controls, 18 cases, 14 controls
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