Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.
Hinks A, Barton A, Shephard N et al.
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Abstract
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Objective: Juvenile idiopathic arthritis (JIA) is a chronic rheumatic disease of childhood. Two well-established genetic factors known to contribute to JIA susceptibility, HLA and PTPN22, account for less than half of the genetic susceptibility to disease; therefore, additional genetic factors have yet to be identified. The purpose of this study was to perform a systematic search of the genome to identify novel susceptibility loci for JIA.
279 European ancestry cases, 184 European ancestry controls
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