A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.
Perlis RH, Smoller JW, Ferreira MA et al.
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Abstract
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Objective: Lithium remains a first-line treatment for bipolar disorder, but the mechanisms by which it prevents the recurrence of mood episodes are not known. The authors utilized data from a genomewide association study to examine associations between single nucleotide polymorphisms (SNPs) and the outcome of lithium treatment in two cohorts of patients with bipolar I disorder or bipolar II disorder.
458 lithium-treated cases, 719 non-lithium treated cases
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