GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
Aouizerat BE, Vittinghoff E, Musone SL et al.
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Abstract
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Epidemiologic evidence suggests a heritable component to risk for sudden cardiac arrest independent of risk for myocardial infarction. Recent candidate gene association studies for community sudden cardiac arrests have focused on a limited number of biological pathways and yielded conflicting results. We sought to identify novel gene associations for sudden cardiac arrest in patients with coronary artery disease by performing a genome-wide association study.
88 European ancestry cases, 517 European ancestry controls
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