Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.
Thompson AJ, Clark PJ, Singh A et al.
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Background & aims: Interferon-alfa (IFN)-related cytopenias are common and may be dose-limiting. We performed a genome wide association study on a well-characterized genotype 1 HCV cohort to identify genetic determinants of peginterferon-α (pegIFN)-related thrombocytopenia, neutropenia, and leukopenia.
984 European ancestry with genotype 1 HCV cases, 201 African American genotype 1 HCV cases, 99 Hispanic genotype 1 HCV cases
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