Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
Smith AK, Fang H, Whistler T et al.
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Abstract
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There is no consistent evidence of specific gene(s) or molecular pathways that contribute to the pathogenesis, therapeutic intervention or diagnosis of chronic fatigue syndrome (CFS). While multiple studies support a role for genetic variation in CFS, genome-wide efforts to identify associated loci remain unexplored. We employed a novel convergent functional genomics approach that incorporates the findings from single-nucleotide polymorphism (SNP) and mRNA expression studies to identify associations between CFS and novel candidate genes for further investigation.
40 European ancestry cases, 40 European ancestry controls
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