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GWAS Study

Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.

Brockschmidt FF, Heilmann S, Ellis JA et al.

22032556 PubMed ID
GWAS Study Type
1810 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

BF
Brockschmidt FF
HS
Heilmann S
EJ
Ellis JA
ES
Eigelshoven S
HS
Hanneken S
HC
Herold C
MS
Moebus S
AM
Alblas MA
LB
Lippke B
KN
Kluck N
PL
Priebe L
DF
Degenhardt FA
JR
Jamra RA
MC
Meesters C
JK
Jöckel KH
ER
Erbel R
HS
Harrap S
SJ
Schumacher J
FH
Fröhlich H
KR
Kruse R
HA
Hillmer AM
BT
Becker T
NM
Nöthen MM
Chapter II

Abstract

Summary of the research findings

Male-pattern baldness (androgenetic alopecia, AGA) is the most common form of hair loss among humans. Research has shown that it is caused by genetic factors. Numerous studies have unequivocally identified two major genetic risk loci for AGA: the X-chromosomal AR/EDA2R locus, and the PAX1/FOXA2 locus on chromosome 20.

581 European ancestry male cases, 617 European ancestry male controls

Chapter III

Study Statistics

Key metrics and study information

1810
Total Participants
GWAS
Study Type
Yes
Replicated
461 European ancestry male cases, 151 European ancestry male controls
Replication Participants
European
Ancestry
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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