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GWAS Study

ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior.

Chen XD, Xiong DH, Yang TL et al.

22613542 PubMed ID
GWAS Study Type
6592 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

CX
Chen XD
XD
Xiong DH
YT
Yang TL
PY
Pei YF
GY
Guo YF
LJ
Li J
YF
Yang F
PF
Pan F
TL
Tan LJ
YH
Yan H
LX
Liu XG
LS
Lei SF
LX
Li X
NL
Ning LL
ZX
Zhu XZ
LS
Levy S
KH
Kranzler HR
FL
Farrer LA
GJ
Gelernter J
RR
Recker RR
DH
Deng HW
Chapter II

Abstract

Summary of the research findings

Alcohol dependence (AD) is a complex disorder characterized by impaired control over drinking. It is determined by both genetic and environmental factors. The recent approach of genome-wide association study (GWAS) is a powerful tool for identifying complex disease-associated susceptibility alleles, however, a few GWASs have been conducted for AD, and their results are largely inconsistent. The present study aimed to screen the loci associated with alcohol-related phenotypes using GWAS technology.

904 European ancestry individuals

Chapter III

Study Statistics

Key metrics and study information

6592
Total Participants
GWAS
Study Type
Yes
Replicated
1,972 European ancestry individuals from 593 families, 761 European ancestry individuals, 2,955 Han Chinese ancestry individuals
Replication Participants
European, East Asian
Ancestry
U.S., China
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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