Impact of ancestry and common genetic variants on QT interval in African Americans.
Smith JG, Avery CL, Evans DS et al.
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Abstract
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Ethnic differences in cardiac arrhythmia incidence have been reported, with a particularly high incidence of sudden cardiac death and low incidence of atrial fibrillation in individuals of African ancestry. We tested the hypotheses that African ancestry and common genetic variants are associated with prolonged duration of cardiac repolarization, a central pathophysiological determinant of arrhythmia, as measured by the electrocardiographic QT interval.
13,105 African American individuals
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