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GWAS Study

Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.

Yu B, Barbalic M, Brautbar A et al.

23247143 PubMed ID
GWAS Study Type
11544 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

YB
Yu B
BM
Barbalic M
BA
Brautbar A
NV
Nambi V
HR
Hoogeveen RC
TW
Tang W
MT
Mosley TH
RJ
Rotter JI
DC
deFilippi CR
OC
O'Donnell CJ
KS
Kathiresan S
RK
Rice K
HS
Heckbert SR
BC
Ballantyne CM
PB
Psaty BM
BE
Boerwinkle E
Chapter II

Abstract

Summary of the research findings

High levels of cardiac troponin T, measured by a highly sensitive assay (hs-cTnT), are strongly associated with incident coronary heart disease and heart failure. To date, no large-scale genome-wide association study of hs-cTnT has been reported. We sought to identify novel genetic variants that are associated with hs-cTnT levels.

9,491 European ancestry individuals, up to 2,053 African American individuals

Chapter III

Study Statistics

Key metrics and study information

11544
Total Participants
GWAS
Study Type
No
Replicated
European, African American or Afro-Caribbean
Ancestry
U.S.
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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