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GWAS Study

Meta-analysis identifies a MECOM gene as a novel predisposing factor of osteoporotic fracture.

Hwang JY, Lee SH, Go MJ et al.

23349225 PubMed ID
GWAS Study Type
4563 Participants
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Chapter I

Publication Details

Comprehensive information about this research publication

Authors

HJ
Hwang JY
LS
Lee SH
GM
Go MJ
KB
Kim BJ
KI
Kou I
IS
Ikegawa S
GY
Guo Y
DH
Deng HW
RS
Raychaudhuri S
KY
Kim YJ
OJ
Oh JH
KY
Kim Y
MS
Moon S
KD
Kim DJ
KH
Koo H
CM
Cha MJ
LM
Lee MH
YJ
Yun JY
YH
Yoo HS
KY
Kang YA
CE
Cho EH
KS
Kim SW
OK
Oh KW
KM
Kang MI
SH
Son HY
KS
Kim SY
KG
Kim GS
HB
Han BG
CY
Cho YS
CM
Cho MC
LJ
Lee JY
KJ
Koh JM
Chapter II

Abstract

Summary of the research findings

Osteoporotic fracture (OF) as a clinical endpoint is a major complication of osteoporosis. To screen for OF susceptibility genes, we performed a genome-wide association study and carried out de novo replication analysis of an East Asian population.

288 Korean ancestry cases, 1,139 Korean ancestry controls

Chapter III

Study Statistics

Key metrics and study information

4563
Total Participants
GWAS
Study Type
Yes
Replicated
831 East Asian ancestry cases, 2305 East Asian ancestry controls
Replication Participants
East Asian
Ancestry
Republic of Korea, Japan
Recruitment Country
Chapter IV

Analysis

Comprehensive review of health and genetic findings

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