A colorectal cancer susceptibility new variant at 4q26 in the Spanish population identified by genome-wide association analysis.
Real LM, Ruiz A, Gayán J et al.
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Abstract
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Non-hereditary colorectal cancer (CRC) is a complex disorder resulting from the combination of genetic and non-genetic factors. Genome-wide association studies (GWAS) are useful for identifying such genetic susceptibility factors. However, the single loci so far associated with CRC only represent a fraction of the genetic risk for CRC development in the general population. Therefore, many other genetic risk variants alone and in combination must still remain to be discovered. The aim of this work was to search for genetic risk factors for CRC, by performing single-locus and two-locus GWAS in the Spanish population.
480 European ancestry cases, 801 European ancestry controls
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